Fmoc-Ser(Bzl)-OH
Fmoc-Ser(Bzl)-OH (CAS: 83792-48-7), with the molecular formula C25H23NO5, is a key protected amino acid derivative. It features the Fmoc protecting group on the alpha-amino nitrogen and a benzyl protecting group on the serine hydroxyl side chain. This compound is primarily utilised in solid-phase peptide synthesis (SPPS) and solution-phase synthesis for the controlled construction of peptides containing serine residues.
- IUPAC
- Fmoc-O-benzyl-L-serine
- Synonyms
- Fmoc-O-benzyl-L-serine
Solid-Phase Peptide Synthesis (SPPS)
Fmoc-Ser(Bzl)-OH is widely employed as a building block in SPPS. The Fmoc group allows for facile deprotection under mild basic conditions, enabling sequential amino acid coupling.
Solution-Phase Peptide Synthesis
In solution-phase approaches, this derivative facilitates the controlled formation of peptide bonds. The benzyl side-chain protection is stable during Fmoc deprotection but can be removed later under hydrogenolysis conditions.
Bioconjugation and Chemical Biology
The compound serves as a precursor for introducing serine residues into peptides for applications in chemical biology, such as protein modification studies or the synthesis of biologically active peptides.
Research and Development
It is an essential reagent for researchers in organic chemistry, medicinal chemistry, and biochemistry developing novel peptide-based therapeutics or probes.
| Molecular weight | 417.45 |
|---|---|
| Empirical formula | C25H23NO5 |
| Assay | ≥98.0% (HPLC) |
| Optical activity | [α]20/D +24±2°, c = 1% in ethyl acetate |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Ser(Bzl)-OH used for?
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Fmoc-Ser(Bzl)-OH is primarily used in solid-phase and solution-phase peptide synthesis as a protected serine building block for constructing peptide chains.
What are the CAS number and molecular formula of Fmoc-Ser(Bzl)-OH?
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The CAS number for Fmoc-Ser(Bzl)-OH is 83792-48-7, and its molecular formula is C25H23NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Ser(Bzl)-OH with an assay of ≥98.0% (HPLC). This is a research grade material and is not represented as USP, BP, or EP grade.
How should Fmoc-Ser(Bzl)-OH be handled and stored?
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Handle Fmoc-Ser(Bzl)-OH with appropriate personal protective equipment, including eyeshields and gloves. Store at 2-8°C. In Germany, it is classified as WGK 3 (Water Hazard Class 3), indicating a high hazard to water.
Is Fmoc-Ser(Bzl)-OH shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals and can export Fmoc-Ser(Bzl)-OH worldwide.
How can I request a quote or sample?
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To request a quote or a sample of Fmoc-Ser(Bzl)-OH, please contact our sales team through the TSS website or by calling our customer service line.
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