Fmoc-Ser(tBu)-OH

CAS 71989-33-8C22H25NO5Chemical Synthesis

Fmoc-Ser(tBu)-OH (CAS 71989-33-8), a protected amino acid derivative with the molecular formula C22H25NO5, is essential in solid-phase peptide synthesis. The Fmoc group provides temporary protection for the alpha-amino function, while the tert-butyl ether protects the serine side chain hydroxyl. This strategy allows for controlled chain elongation in peptide assembly, facilitating the synthesis of complex peptides and peptidomimetics for research and pharmaceutical development.

IUPAC: Fmoc-O-tert-butyl-L-serine
Synonyms: Fmoc-O-tert-butyl-L-serine

Email us

Fmoc-Ser(tBu)-OH (C22H25NO5) — chemical structure, CAS 71989-33-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesAnalytical StandardsAnalytical/ChromatographyChemical BiologyChemical SynthesisFM - FZPeptide ChemistrySerine

01 /Applications

Peptide Synthesis

Utilised as a crucial building block in solid-phase peptide synthesis (SPPS) to introduce serine residues with orthogonal protection strategies. The Fmoc and tert-butyl groups allow for selective deprotection and coupling steps.

Pharmaceutical Research

An intermediate in the synthesis of peptide-based therapeutics and drug candidates, enabling the creation of modified peptides for biological studies.

Chemical Biology

Applied in the development of peptide probes, labelled peptides, and other tools for investigating biological processes at a molecular level.

Analytical Standards

Serves as a reference standard in analytical chemistry, particularly in chromatography, for the identification and quantification of related compounds.

02 /Properties

Molecular weight	383.44
Empirical formula	C22H25NO5
Assay	≥98.0% (HPLC)
Optical activity	[α]20/D +25.5±1°, c = 1% in ethyl acetate
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

71989-33-8

MDL number

MFCD00037127

Beilstein registry

3632013

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-Ser(tBu)-OH used for?

Fmoc-Ser(tBu)-OH is primarily used as a protected amino acid building block in solid-phase peptide synthesis and for the preparation of peptide-based pharmaceuticals and research tools.

What is the CAS number and formula for Fmoc-Ser(tBu)-OH?

The CAS number is 71989-33-8 and the empirical formula is C22H25NO5.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-Ser(tBu)-OH with an assay of ≥98.0% by HPLC. We do not represent this product as USP, BP, or EP grade.

How should Fmoc-Ser(tBu)-OH be stored and handled safely?

It should be stored at 2-8°C. For safe handling, wear eyeshields, gloves, and use a type N95 (US) or type P1 (EN143) respirator filter. Ensure adequate ventilation.

Is Fmoc-Ser(tBu)-OH a controlled substance?

Based on the provided data, Fmoc-Ser(tBu)-OH is not indicated as a controlled substance.

How are products like Fmoc-Ser(tBu)-OH packed, shipped, and exported by TSS?

Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, ensuring appropriate packaging and adherence to international shipping regulations for safe and compliant delivery worldwide.