Fmoc-Ser(tBu)-OPfp
Fmoc-Ser(tBu)-OPfp (CAS: 105751-13-1) is a protected amino acid derivative with the molecular formula C28H24F5NO5. This compound serves as a valuable building block in peptide synthesis. Its structure incorporates the Fmoc protecting group for the N-terminus, a tert-butyl protecting group for the serine hydroxyl, and a pentafluorophenyl ester for activated coupling. This combination facilitates controlled peptide chain elongation.
- IUPAC
- Fmoc-O-tert-butyl-L-serine pentafluorophenyl ester
Peptide Synthesis
Fmoc-Ser(tBu)-OPfp is widely used in solid-phase and solution-phase peptide synthesis. The Fmoc group allows for orthogonal deprotection strategies, while the tert-butyl protection prevents side reactions on the serine hydroxyl during coupling. The activated pentafluorophenyl ester enables efficient amide bond formation.
Chemical Biology Research
As a functionalised amino acid, this reagent finds application in the synthesis of modified peptides for biochemical and biophysical studies. These can include peptides used to investigate protein-protein interactions, enzyme mechanisms, or as probes in biological systems.
Pharmaceutical Intermediate Synthesis
The compound can be employed in the multi-step synthesis of complex pharmaceutical agents that incorporate serine residues within their structure. Its protected nature ensures regioselective incorporation into larger molecules.
Organic Synthesis
Beyond peptides, Fmoc-Ser(tBu)-OPfp may be used in the construction of specialised organic molecules where a protected serine moiety is required. The pentafluorophenyl ester offers good reactivity for acylation reactions.
| Molecular weight | 549.49 |
|---|---|
| Empirical formula | C28H24F5NO5 |
| Assay | ≥90% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Ser(tBu)-OPfp used for?
+
Fmoc-Ser(tBu)-OPfp is primarily used as a protected amino acid building block in solid-phase and solution-phase peptide synthesis, as well as in chemical biology research and the synthesis of pharmaceutical intermediates.
What are the CAS number and formula for Fmoc-Ser(tBu)-OPfp?
+
The CAS number for Fmoc-Ser(tBu)-OPfp is 105751-13-1, and its empirical formula (Hill notation) is C28H24F5NO5.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Fmoc-Ser(tBu)-OPfp with an assay of ≥90% (HPLC). We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.
How should Fmoc-Ser(tBu)-OPfp be stored and handled?
+
This compound requires storage at 2-8°C. Handling should involve appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter, as it is classified under WGK 3 in Germany.
How is Fmoc-Ser(tBu)-OPfp packed, shipped, and exported?
+
Tech Serve Solutions securely packs, ships, and exports fine chemicals globally, adhering to all relevant regulations to ensure safe and timely delivery to our customers.
How can I request a sample or quote for Fmoc-Ser(tBu)-OPfp?
+
To request a sample or a quote, please contact our sales team directly through the website or by phone, providing the product name and CAS number (105751-13-1).
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis