Fmoc-Pro-OPfp
Fmoc-Pro-OPfp (CAS 86060-90-4), with the molecular formula C26H18F5NO4 and a molecular weight of 503.42 g/mol, is a key derivative in peptide synthesis. This compound is recognised for its role in introducing protected proline residues into peptide chains. It is a valuable reagent for researchers and chemists engaged in the synthesis of complex peptides and peptidomimetics, particularly within the fields of chemical biology and drug discovery.
- IUPAC
- N-(9-Fluorenylmethoxycarbonyl)-L-proline pentafluorophenyl ester,Fmoc-L-proline pentafluorophenyl ester
- Synonyms
- N-(9-Fluorenylmethoxycarbonyl)-L-proline pentafluorophenyl esterFmoc-L-proline pentafluorophenyl ester
Peptide Synthesis
Fmoc-Pro-OPfp is widely used as a building block in solid-phase and solution-phase peptide synthesis. Its Fmoc protecting group allows for facile deprotection under mild basic conditions, enabling stepwise peptide chain elongation.
Chemical Biology Research
This compound facilitates the incorporation of proline, an important imino acid, into peptides for studying protein structure, function, and interactions. It is employed in creating modified peptides for biological assays.
Drug Discovery and Development
As an intermediate in the synthesis of peptidomimetics and peptide-based therapeutics, Fmoc-Pro-OPfp contributes to the development of new pharmaceutical agents.
Organic Synthesis
Beyond peptide chemistry, the reactive pentafluorophenyl ester moiety can be used in various coupling reactions and derivatisations in general organic synthesis.
| Molecular weight | 503.42 |
|---|---|
| Empirical formula | C26H18F5NO4 |
| Assay | ≥96.0% |
| Storage temperature | 2-8°C |
| Melting point | 127-129 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Pro-OPfp used for?
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Fmoc-Pro-OPfp is primarily used in peptide synthesis as a protected proline building block, facilitating the incorporation of proline residues into peptide chains for applications in chemical biology and drug discovery.
What is the CAS number and formula for Fmoc-Pro-OPfp?
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The CAS number for Fmoc-Pro-OPfp is 86060-90-4, and its empirical formula is C26H18F5NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Pro-OPfp with an assay of ≥96.0%. We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade, and it is intended for research and laboratory use.
How should Fmoc-Pro-OPfp be handled and stored?
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Handle Fmoc-Pro-OPfp with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or P1 (EN143) respirator filter is recommended. It should be stored at 2-8°C.
Is Fmoc-Pro-OPfp a controlled substance?
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The provided data does not indicate that Fmoc-Pro-OPfp is a controlled substance.
How is Fmoc-Pro-OPfp packed, shipped, and exported?
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Fmoc-Pro-OPfp is carefully packed to maintain its integrity during transit and is available for domestic and international export by Tech Serve Solutions.
How can I request a sample or quote for Fmoc-Pro-OPfp?
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To request a sample or a quotation for Fmoc-Pro-OPfp, please contact our sales department through the website or by phone.
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