Fmoc-Sar-OH
Fmoc-Sar-OH (CAS 77128-70-2), with the molecular formula C18H17NO4 and a molecular weight of 311.33 g/mol, is a derivative of the amino acid glycine. It is a crucial building block in solid-phase peptide synthesis, particularly for incorporating N-methylated amino acids into peptide chains. This compound is essential for researchers and chemists engaged in peptide research, drug discovery, and the development of novel biomaterials requiring specific peptide sequences.
- IUPAC
- Fmoc-N-methylglycine,Fmoc-sarcosine
- Synonyms
- Fmoc-N-methylglycine, Fmoc-sarcosine
Peptide Synthesis
Fmoc-Sar-OH is extensively used as a protected amino acid derivative in solid-phase peptide synthesis (SPPS). Its Fmoc protecting group allows for orthogonal deprotection strategies, facilitating the controlled assembly of peptide chains. It is particularly valuable for introducing N-methylated glycine residues, which can influence peptide conformation and stability.
Chemical Biology Research
In chemical biology, Fmoc-Sar-OH serves as a reagent for creating modified peptides with tailored properties. These modifications can impact biological activity, metabolic stability, and receptor binding, making it a useful tool for probing biological systems and developing peptide-based therapeutics.
Drug Discovery and Development
The incorporation of N-methylated amino acids, facilitated by Fmoc-Sar-OH, can enhance the pharmacokinetic profile of peptide drugs. This includes improving oral bioavailability and resistance to enzymatic degradation, making it a significant component in the design of next-generation peptide pharmaceuticals.
| Molecular weight | 311.33 |
|---|---|
| Empirical formula | C18H17NO4 |
| Assay | ≥98.0% |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Sar-OH used for?
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Fmoc-Sar-OH (CAS 77128-70-2) is primarily used as a protected amino acid derivative in solid-phase peptide synthesis for the introduction of N-methylated glycine residues into peptide sequences. It is valuable in chemical biology research and drug discovery for creating modified peptides with enhanced stability and tailored properties.
What are the CAS number and molecular formula for Fmoc-Sar-OH?
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The CAS number for Fmoc-Sar-OH is 77128-70-2, and its empirical formula (Hill notation) is C18H17NO4.
What grade and purity does Tech Serve Solutions supply for Fmoc-Sar-OH?
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Tech Serve Solutions supplies Fmoc-Sar-OH with a purity of ≥98.0%. This product is typically considered a research or technical grade chemical and is not supplied as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling requirements for Fmoc-Sar-OH?
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Handling Fmoc-Sar-OH requires appropriate personal protective equipment, including eyeshields and gloves. A respirator filter of type N95 (US) or P1 (EN143) is recommended. The compound is classified with WGK Germany 3, indicating a high hazard to water.
How is Fmoc-Sar-OH typically shipped and exported?
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Fmoc-Sar-OH is stored at 2-8°C to maintain its stability. Tech Serve Solutions, a global supplier and exporter, can provide information on specific shipping and export procedures upon inquiry.
How can I request a sample or a quote for Fmoc-Sar-OH?
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To request a sample or obtain a quote for Fmoc-Sar-OH, please contact our sales department through the Tech Serve Solutions website or by phone. Our team will assist you with your requirements.
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