Fmoc-Pro-Bt
Fmoc-Pro-Bt (CAS 1155875-68-5), with the molecular formula C26H22N4O3 and a molecular weight of 438.48 g/mol, is a Benzotriazole amino acid derivative. This compound serves as a versatile reagent primarily utilised in the synthesis of peptides, peptidomimetics, and their associated conjugates. It is widely employed in chemical biology and advanced peptide chemistry research.
- IUPAC
- (S)-(9H-Fluoren-9-yl)methyl 2-(1H-benzo[d][1,2,3]triazole-1-carbonyl)pyrrolidine-1-carboxylate,(S)-N-Fmoc-2-(benzotriazolylcarbonyl)pyrrolidine
Peptide Synthesis
Fmoc-Pro-Bt functions as a key intermediate in the solid-phase or solution-phase synthesis of peptides. Its benzotriazole moiety acts as an efficient leaving group, facilitating amide bond formation.
Peptidomimetic Development
This derivative is instrumental in creating peptidomimetics, such as aminoxypeptides and depsipeptides, which mimic the structure and function of natural peptides but with enhanced stability or modified properties.
Peptide Conjugate Preparation
Fmoc-Pro-Bt is employed for the synthesis of diverse peptide conjugates, including those linked to fluorescent labels or other functional molecules, enabling applications in diagnostics and biochemical research.
| Molecular weight | 438.48 |
|---|---|
| Empirical formula | C26H22N4O3 |
| Assay | 95% |
| Storage temperature | 2-8°C |
| Application | Benzotriazole amino acids, or aminoacylbenzotriazolides, are versatile reagents for synthesizing peptides as well as their mimetics and conjugates. Benzotriazole amino acids have been used for the preparation of diverse derivatives including:• Polypeptidal benzotriazolides1• Peptidomimetics, such as aminoxypeptides2, depsipeptides3 and heterocyclic peptidomimetics4• Tagged peptides and peptidomimetics, particularly those with fluorescent labels5,6• N, O, S, and C linked peptide conjugates6 |
| Melting point | 163-168 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Pro-Bt used for?
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Fmoc-Pro-Bt is primarily used as a versatile reagent in the synthesis of peptides, peptidomimetics, and peptide conjugates. It is valuable in chemical biology and advanced peptide chemistry.
What are the CAS number and formula for Fmoc-Pro-Bt?
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The CAS number for Fmoc-Pro-Bt is 1155875-68-5, and its empirical formula is C26H22N4O3.
What grade and purity does Tech Serve Solutions supply for Fmoc-Pro-Bt?
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Tech Serve Solutions supplies Fmoc-Pro-Bt with a minimum assay of 95%. This product is intended for research and laboratory use and is not represented as USP, BP, or EP grade.
What are the safety and handling considerations for Fmoc-Pro-Bt?
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Fmoc-Pro-Bt is classified as a Warning substance, indicated by GHS07. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment in a well-ventilated area. Refer to the Safety Data Sheet for full details.
How is Fmoc-Pro-Bt shipped and exported?
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Fmoc-Pro-Bt is carefully packed and exported by Tech Serve Solutions, a specialist global supplier, adhering to all relevant shipping regulations for chemical compounds.
How can I request a sample or quote for Fmoc-Pro-Bt?
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To request a sample or a quote for Fmoc-Pro-Bt, please contact our sales team directly through the provided contact channels on the Tech Serve Solutions website.
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