Fmoc-Phe-OH
Fmoc-Phe-OH (CAS: 35661-40-6), with the molecular formula C24H21NO4 and a molecular weight of 387.43 g/mol, is a vital derivative of L-phenylalanine. This compound is predominantly utilised in solid-phase peptide synthesis (SPPS) as a protected amino acid. Its N-terminal Fmoc group allows for controlled, stepwise chain elongation, making it indispensable for researchers in peptide chemistry, chemical biology, and medicinal chemistry.
- IUPAC
- N-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine,Fmoc-L-phenylalanine
- Synonyms
- N-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine,Fmoc-L-phenylalanine
Solid-Phase Peptide Synthesis (SPPS)
Fmoc-Phe-OH is a cornerstone reagent in SPPS. The acid-labile Fmoc protecting group on the alpha-amino group allows for selective deprotection under mild basic conditions, facilitating sequential coupling of amino acids to build peptide chains.
Peptide Library Synthesis
In the construction of combinatorial peptide libraries for drug discovery and screening, Fmoc-Phe-OH is routinely employed. Its incorporation enables the systematic variation of phenylalanine residues within peptide sequences.
Chemical Biology Research
This protected amino acid is used in the synthesis of modified peptides and peptidomimetics for studying biological processes, protein-ligand interactions, and developing biochemical probes.
Medicinal Chemistry
Fmoc-Phe-OH serves as a building block in the synthesis of novel therapeutic agents and drug candidates where phenylalanine or its analogues are part of the pharmacophore.
| Molecular weight | 387.43 |
|---|---|
| Empirical formula | C24H21NO4 |
| Assay | ≥98.0% (HPLC) |
| Optical activity | [α]20/D −40±2°, c = 1% in DMF |
| Storage temperature | 2-8°C |
| Melting point | 180-187 °C(lit.)180-187 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Phe-OH used for?
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Fmoc-Phe-OH is primarily used as a protected building block in solid-phase peptide synthesis (SPPS) for the construction of peptides and peptidomimetics.
What are the CAS number and formula for Fmoc-Phe-OH?
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The CAS number for Fmoc-Phe-OH is 35661-40-6, and its molecular formula is C24H21NO4.
What grade and purity does Tech Serve Solutions supply for Fmoc-Phe-OH?
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Tech Serve Solutions supplies Fmoc-Phe-OH with an assay of ≥98.0% (HPLC). This product is suitable for research and chemical synthesis applications; TSS does not represent it as USP, BP, or EP grade.
How should Fmoc-Phe-OH be handled and stored?
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Fmoc-Phe-OH should be handled with appropriate personal protective equipment, including eyeshields and gloves. It is recommended to store the compound at 2-8°C to maintain its integrity.
Is Fmoc-Phe-OH a controlled substance?
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Based on the provided data, Fmoc-Phe-OH is not listed as a controlled substance.
How is Fmoc-Phe-OH shipped and exported by TSS?
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Tech Serve Solutions, as a specialist global supplier and exporter of fine chemicals, ships Fmoc-Phe-OH under conditions appropriate for its storage requirements (2-8°C), complying with all relevant export regulations.
How can I request a sample or quote for Fmoc-Phe-OH?
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To request a sample or a quotation for Fmoc-Phe-OH, please contact our sales department through the website or via direct enquiry, providing your specific requirements.
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