Fmoc-Phe(4-Cl)-OH
Fmoc-Phe(4-Cl)-OH (CAS: 175453-08-4) is a substituted phenylalanine derivative featuring the Fmoc protecting group. With a molecular weight of 421.87 and empirical formula C24H20ClNO4, this compound is primarily employed in peptide synthesis. Its structure, incorporating a chlorinated phenyl ring, makes it valuable for introducing modified amino acid residues into peptide chains, facilitating research in chemical biology and drug discovery.
- IUPAC
- Fmoc-4-chloro-L-phenylalanine
- Synonyms
- Fmoc-4-chloro-L-phenylalanine
Peptide Synthesis
Fmoc-Phe(4-Cl)-OH serves as a building block in solid-phase peptide synthesis (SPPS), allowing for the incorporation of unnatural amino acid residues with a chlorinated phenyl side chain. This is crucial for creating peptides with modified properties for research and development.
Chemical Biology Research
The unique structural features of this compound make it useful for probing protein structure-function relationships and for developing novel biologically active peptides. Its chlorinated phenylalanine moiety can influence peptide conformation and interactions.
Drug Discovery and Development
As an unnatural amino acid derivative, Fmoc-Phe(4-Cl)-OH is employed in the synthesis of peptide-based drug candidates. Modifications like chlorination can enhance metabolic stability or receptor binding affinity.
Chemical Synthesis
This compound is a versatile reagent for synthetic organic chemists engaged in the construction of complex molecules. It provides a readily available source of a protected, chlorinated phenylalanine for further chemical transformations.
| Molecular weight | 421.87 |
|---|---|
| Empirical formula | C24H20ClNO4 |
| Assay | ≥98.0% |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Phe(4-Cl)-OH used for?
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Fmoc-Phe(4-Cl)-OH is primarily used as a protected amino acid building block in peptide synthesis, particularly for incorporating chlorinated phenylalanine residues into peptide chains for research in chemical biology, drug discovery, and other synthetic applications.
What is the CAS number and formula for Fmoc-Phe(4-Cl)-OH?
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The CAS number for Fmoc-Phe(4-Cl)-OH is 175453-08-4. Its empirical formula is C24H20ClNO4, and it has a molecular weight of 421.87.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Phe(4-Cl)-OH with a purity of ≥98.0%. This product is intended for research and synthesis purposes; TSS does not represent it as USP, BP, EP, or other pharmacopoeial grades.
How should Fmoc-Phe(4-Cl)-OH be handled and stored?
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Handle Fmoc-Phe(4-Cl)-OH with appropriate personal protective equipment, including eyeshields and gloves. It should be stored at 2-8°C. Refer to the safety data sheet for comprehensive handling information.
Is Fmoc-Phe(4-Cl)-OH a controlled substance?
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Based on the provided data, Fmoc-Phe(4-Cl)-OH is not listed as a controlled substance. However, users should always comply with local regulations.
How is Fmoc-Phe(4-Cl)-OH packed and shipped?
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Fmoc-Phe(4-Cl)-OH is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions to meet the needs of researchers and manufacturers worldwide.
How can I request a sample or quote for Fmoc-Phe(4-Cl)-OH?
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To request a sample or a quote for Fmoc-Phe(4-Cl)-OH, please contact our sales team through the website or by phone, providing your contact details and required quantity.
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