3-Methoxybenzyl chloride
3-Methoxybenzyl chloride (CAS: 824-98-6), with the molecular formula C8H9ClO, is a key organic building block. This compound, featuring an ether and a benzyl chloride functional group, serves as a valuable intermediate in organic synthesis. It is particularly useful for introducing the 3-methoxybenzyl moiety into various molecular structures, finding application in the development of complex organic molecules and pharmaceutical intermediates.
- IUPAC
- 3-(Chloromethyl)anisole
- Synonyms
- 3-(Chloromethyl)anisole
Alkylation Reactions
3-Methoxybenzyl chloride is employed as an alkylating agent to introduce the 3-methoxybenzyl group. For instance, it has been used in the alkylation of quinolinone derivatives in the presence of bases like sodium hydride.
Synthesis of Diarylmethenes
This compound facilitates the synthesis of diarylmethanes through palladium-catalyzed cross-coupling reactions. It reacts with organozinc reagents to form new carbon-carbon bonds, a critical step in constructing complex aromatic systems.
Organic Synthesis Intermediate
As a versatile building block, 3-Methoxybenzyl chloride is integral to multi-step synthetic pathways in academic research and industrial chemical production, enabling access to a range of functionalised organic molecules.
| Molecular weight | 156.61 |
|---|---|
| Linear formula | CH3OC6H4CH2Cl |
| Assay | 97% |
| Boiling point | 124 °C/13 mmHg(lit.) |
| Density | 1.078 g/mL at 25 °C(lit.)1.078 g/mL |
| Refractive index | n20/D 1.544(lit.) |
| Storage temperature | 2-8°C |
| Contains / stabiliser | potassium carbonate as stabilizer |
| Application | 3-Methoxybenzyl chloride was used to alkylate 8-benzyloxy-2(1H)-quinolinone in the presence of DMF and NaH1. It was also used in the synthesis of diarylmethanes via in situ organozinc-mediated, palladium-catalyzed cross-coupling between benzyl and aryl halide2. |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 101 °C / 213.8 °F1.078 g/mL |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Methoxybenzyl chloride used for?
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3-Methoxybenzyl chloride is used as an intermediate in organic synthesis, particularly for alkylation reactions and the synthesis of diarylmethanes. It serves as a valuable building block for creating more complex organic molecules.
What are the CAS number and formula for 3-Methoxybenzyl chloride?
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The CAS number for 3-Methoxybenzyl chloride is 824-98-6, and its molecular formula is C8H9ClO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Methoxybenzyl chloride with an assay of 97%. This product is intended for research and technical use; TSS does not represent it as USP, BP, or EP grade.
How should 3-Methoxybenzyl chloride be handled safely?
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3-Methoxybenzyl chloride is classified as Danger, with hazard statement H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, including a full-face respirator, gloves, and goggles, must be used. Handle in a well-ventilated area and follow all safety precautions.
How is 3-Methoxybenzyl chloride packed and shipped?
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3-Methoxybenzyl chloride is shipped as a hazardous material, UN 3265, Class 8, Packing Group II. Storage at 2-8°C is recommended. TSS adheres to all regulations for exporting hazardous chemicals.
How can I request a quote or sample of 3-Methoxybenzyl chloride?
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To request a quote or a sample of 3-Methoxybenzyl chloride, please contact our sales department through the website or by phone. Provide your details and the required quantity.
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