4-Fluoro-2-methoxyphenylboronic acid

CAS 179899-07-1FC6H3(OCH3)B(OH)2Chemical Synthesis

4-Fluoro-2-methoxyphenylboronic acid (CAS: 179899-07-1), with the molecular formula FC6H3(OCH3)B(OH)2 and a molar mass of 169.95 g/mol, is a valuable aryl boronic acid derivative. It serves as a key reactant in Suzuki-Miyaura cross-coupling reactions and is instrumental in the synthesis of various biologically active molecules, including potential therapeutic agents.

IUPAC: 4-Fluoro-2-methoxybenzeneboronic acid
Synonyms: 4-Fluoro-2-methoxybenzeneboronic acid

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4-Fluoro-2-methoxyphenylboronic acid (FC6H3(OCH3)B(OH)2) — chemical structure, CAS 179899-07-1; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronic AcidsBoronic AcidsChemical Synthesis

01 /Applications

Suzuki-Miyaura Cross-Coupling Reactions

This compound is a versatile reactant for Suzuki-Miyaura cross-coupling reactions, facilitating the synthesis of complex heterobiaryl structures essential in medicinal chemistry research.

Synthesis of Biologically Active Molecules

It acts as a crucial precursor in the preparation of diverse biologically active molecules, such as GSK-3β inhibitors, NR2B subtype NMDA receptor antagonists with antidepressant activity, and CB1 antagonists.

Antithrombotic Drug Synthesis

Utilised in Suzuki and Still coupling reactions for the development of novel antithrombotic agents, highlighting its importance in pharmaceutical research.

02 /Properties

Molecular weight	169.95
Linear formula	FC6H3(OCH3)B(OH)2
Application	Reactant involved in:• Suzuki-Miyaura cross-coupling reactions for synthesis of heterobiaryls1• Suzuki and Still coupling for synthesis of antithrombotic drugs2Reactant / precursor used for the synthesis of biologically active molecules including:• 2-(4-pyridyl)thienopyridinones for use as GSK-3β inhibitors3• Arylheteroarylmethylamines as NR2B subtype of NMDA receptor antagonists with antidepressant activity4• Biphenylketones for use as dual modulators of inflammation and bone loss5• CB1 antagonists6
Melting point	131-136 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

179899-07-1

MDL number

MFCD03788423

PubChem substance

24880183

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 4-Fluoro-2-methoxyphenylboronic acid used for?

4-Fluoro-2-methoxyphenylboronic acid is primarily used as a reactant in Suzuki-Miyaura cross-coupling reactions for the synthesis of heterobiaryls and biologically active molecules, including antithrombotic drugs, GSK-3β inhibitors, and NMDA receptor antagonists.

What are the CAS number and molecular formula?

The CAS number is 179899-07-1 and the molecular formula is FC6H3(OCH3)B(OH)2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this compound as a research or technical grade chemical. We do not represent it as USP, BP, or EP grade unless explicitly stated.

What are the safety and handling considerations?

This compound requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Handle with care, following standard laboratory safety protocols.

Is this product a controlled substance?

The provided data does not indicate that 4-Fluoro-2-methoxyphenylboronic acid is a controlled substance.

How can I request a sample or quote?

To request a sample or a quote, please contact the Tech Serve Solutions sales team through our website or by phone.

How is this chemical packed, shipped, and exported?

Tech Serve Solutions securely packs and prepares chemicals for safe shipment and export, adhering to all relevant international regulations for chemical transport.