4-Fluoro-2-methylaniline
4-Fluoro-2-methylaniline (CAS: 452-71-1), with the molecular formula FC6H3(CH3)NH2 and a molecular weight of 125.14, is a fluorinated aromatic amine. This compound serves as a valuable building block in organic synthesis, particularly in the development of complex molecules within the pharmaceutical and chemical industries. Its specific structure makes it a useful intermediate for introducing a fluorinated methylaniline moiety into target compounds.
- IUPAC
- 2-Amino-5-fluorotoluene,4-Fluoro-o-toluidine
- Synonyms
- 2-Amino-5-fluorotoluene4-Fluoro-o-toluidine
Organic Synthesis Intermediate
4-Fluoro-2-methylaniline is employed as a key intermediate in the synthesis of various organic compounds. Its reactive amine group and fluorinated aromatic ring allow for diverse chemical transformations.
Pharmaceutical Research
This compound can be used in the research and development of novel pharmaceutical agents. The presence of fluorine often imparts desirable properties to drug candidates, such as increased metabolic stability or altered binding affinity.
Agrochemical Development
As a fluorinated aromatic amine, 4-Fluoro-2-methylaniline may find application in the synthesis of new agrochemicals, contributing to the development of pesticides and herbicides.
Material Science
The unique electronic properties conferred by the fluorine atom can make this compound a potential building block for functional materials or specialty polymers.
| Molecular weight | 125.14 |
|---|---|
| Linear formula | FC6H3(CH3)NH2 |
| Assay | 96% |
| Boiling point | 90-92 °C/16 mmHg(lit.) |
| Density | 1.126 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.537(lit.) |
| Application | 4-Fluoro-2-methylaniline was used in the synthesis of 4-fluoro-N-[(E)-{7-methoxy-2-[4-(methylsulfanyl)phenyl]-1-benzofuran-5-yl}methylidene]-2-methylaniline1. |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 88 °C / 190.4 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluoro-2-methylaniline used for?
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4-Fluoro-2-methylaniline is primarily used as an intermediate in organic synthesis, including in pharmaceutical research and the development of agrochemicals and functional materials.
What is the CAS number and chemical formula for 4-Fluoro-2-methylaniline?
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The CAS number is 452-71-1 and the chemical formula is FC6H3(CH3)NH2.
What grade and purity does Tech Serve Solutions supply for 4-Fluoro-2-methylaniline?
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Tech Serve Solutions supplies 4-Fluoro-2-methylaniline with an assay of 96%. We do not represent this product as USP, BP, or EP grade.
How should 4-Fluoro-2-methylaniline be handled safely?
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Handle with appropriate personal protective equipment, including eyeshields, faceshields, gloves, and a suitable respirator, as it is harmful if swallowed, in contact with skin, or inhaled, and causes skin, eye, and respiratory irritation (H302, H312, H315, H319, H332, H335).
Is 4-Fluoro-2-methylaniline available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 4-Fluoro-2-methylaniline.
How can I request a quote or sample for 4-Fluoro-2-methylaniline?
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Please contact our sales team or use the online inquiry form to request a quote or sample for 4-Fluoro-2-methylaniline.
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