(Triisopropylsiloxy)methyl chloride
(Triisopropylsiloxy)methyl chloride (CAS: 217300-17-9) is a silicon-based organic compound with the molecular formula C10H23ClOSi and a molecular weight of 222.83 g/mol. This reagent serves as a valuable tool in chemical synthesis, particularly for protection and derivatization strategies. Its structure allows for the selective introduction of a protected hydroxymethyl group, finding utility in complex organic transformations.
- IUPAC
- (Chloromethoxy)triisopropylsilane,TOMCl
- Synonyms
- (Chloromethoxy)triisopropylsilane, TOMCl

Protecting Group Reagent
Used for the protection of alcohols and other nucleophilic functional groups during multi-step organic synthesis. The triisopropylsiloxy moiety offers steric bulk which can influence reactivity and selectivity.
Derivatization Agent
Can be employed to introduce a (triisopropylsiloxy)methyl group onto various substrates, facilitating characterisation or modification of molecules.
Intermediate in Organic Synthesis
Serves as a building block in the synthesis of more complex organic molecules, particularly where silicon-containing functionalities are desired or useful.
| Molecular weight | 222.83 |
|---|---|
| Empirical formula | C10H23ClOSi |
| Assay | ≥95.0% (GC) |
| Density | 0.96 g/mL at 20 °C(lit.) |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (Triisopropylsiloxy)methyl chloride used for?
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(Triisopropylsiloxy)methyl chloride is primarily used as a protecting group reagent and a derivatization agent in organic synthesis. It facilitates the protection of alcohols and other nucleophilic functional groups, and serves as a building block for more complex molecules.
What is the CAS number and formula for (Triisopropylsiloxy)methyl chloride?
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The CAS number for (Triisopropylsiloxy)methyl chloride is 217300-17-9, and its empirical formula is C10H23ClOSi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (Triisopropylsiloxy)methyl chloride with an assay of ≥95.0% (GC). This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling recommendations for this chemical?
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This chemical requires careful handling. Recommended personal protective equipment includes eyeshields and gloves. Refer to the Safety Data Sheet (SDS) for comprehensive hazard information and handling procedures. Its WGK classification in Germany is 3, indicating a higher level of hazard.
How is (Triisopropylsiloxy)methyl chloride packed, shipped, and exported?
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Our products are carefully packed according to international shipping regulations. Tech Serve Solutions is experienced in exporting fine chemicals globally, ensuring secure and compliant delivery to your laboratory or facility.
How can I request a sample or a quote for (Triisopropylsiloxy)methyl chloride?
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To request a sample or obtain a quote, please visit our website or contact our sales team directly. Provide the product name and CAS number for efficient processing.
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