(Trimethylsilyl)acetic acid

CAS 2345-38-2(CH3)3SiCH2CO2HChemical Synthesis

(Trimethylsilyl)acetic acid (CAS 2345-38-2) is a versatile organosilicon compound with the linear formula (CH3)3SiCH2CO2H and a molecular weight of 132.23 g/mol. This carboxylic acid derivative serves as a valuable building block in organic synthesis. It is commonly employed in the preparation of more complex molecules, particularly in research and development settings within the pharmaceutical and chemical industries.

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(Trimethylsilyl)acetic acid ((CH3)3SiCH2CO2H) — chemical structure, CAS 2345-38-2; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksC1 to C5Carbonyl CompoundsCarboxylic AcidsChemical Synthesis

01 /Applications

Organic Synthesis Intermediate

(Trimethylsilyl)acetic acid is utilised as a synthon in the construction of carbon frameworks. Its silyl group can be strategically employed for protection or directing subsequent reactions, making it a useful component in multi-step synthetic routes.

Pharmaceutical Research

This compound finds application in the discovery and development of new drug candidates. It can be incorporated into molecular structures being screened for biological activity, contributing to the diversity of chemical libraries.

Material Science

The unique properties conferred by the trimethylsilyl group allow for its use in the development of novel materials. It may be involved in the synthesis of polymers or functionalised surfaces where organosilicon characteristics are desired.

02 /Properties

Molecular weight	132.23
Linear formula	(CH3)3SiCH2CO2H
Assay	≥99.0% (T)
Grade	purum
Melting point	39-42 °C(lit.)39-42 °C

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Flash point	95 °C / 203 °F
Water hazard class (WGK, DE)	2
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

2345-38-2

MDL number

MFCD00042651

Beilstein registry

1679394

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (Trimethylsilyl)acetic acid used for?

(Trimethylsilyl)acetic acid is primarily used as a building block in organic synthesis and in pharmaceutical research for the preparation of complex molecules.

What is the CAS number and formula for (Trimethylsilyl)acetic acid?

The CAS number is 2345-38-2 and the linear formula is (CH3)3SiCH2CO2H.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies (Trimethylsilyl)acetic acid in 'purum' grade with an assay of ≥99.0% (T). We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.

How should (Trimethylsilyl)acetic acid be handled?

Handle (Trimethylsilyl)acetic acid with appropriate personal protective equipment including a dust mask type N95 (US), eyeshields, and gloves. It is classified as causing skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Ensure adequate ventilation.