(Trimethylsilyl)isocyanate
(Trimethylsilyl)isocyanate (CAS 1118-02-1) is an organosilicon compound with the linear formula (CH3)3SiNCO and a molecular weight of 115.21 g/mol. This clear, colourless liquid serves as a versatile reagent in organic synthesis. It is primarily utilised as a building block and source of the isocyanate group in the preparation of various chemical intermediates and functionalised molecules.
- IUPAC
- Isocyanatotrimethylsilane
- Synonyms
- Isocyanatotrimethylsilane
Organic Synthesis Reagent
Employed as a key building block, (Trimethylsilyl)isocyanate is used to introduce the isocyanate functional group in complex organic molecules. Its reactivity allows for the formation of carbamates, ureas, and other nitrogen-containing heterocycles.
Preparation of Pharmaceutical Intermediates
This compound finds application in the synthesis pathways for various pharmaceutical intermediates. Its ability to undergo facile reactions makes it valuable in multi-step synthetic routes for biologically active compounds.
Silane Chemistry
As a silyl isocyanate, it can be involved in reactions for the functionalisation of materials or in the synthesis of specialised silane derivatives. The silyl group can act as a protecting group or be replaced in subsequent reactions.
| Molecular weight | 115.21 |
|---|---|
| Linear formula | (CH3)3SiNCO |
| Assay | ≥95% (GC) |
| Boiling point | 90-92 °C(lit.) |
| Density | 0.851 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.396(lit.)n20/D 1.397 |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H331Toxic if inhaled
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -5 °C / 23 °F |
| Transport (UN / ADR) | UN 2478 3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,T |
| Risk statements (R) | 11-23-36/37-42 |
| Safety statements (S) | 23-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (Trimethylsilyl)isocyanate used for?
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(Trimethylsilyl)isocyanate is used as a versatile building block and reagent in organic synthesis, particularly for introducing the isocyanate group into organic molecules and in the preparation of pharmaceutical intermediates.
What is the CAS number and formula for (Trimethylsilyl)isocyanate?
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The CAS number is 1118-02-1 and the linear formula is (CH3)3SiNCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (Trimethylsilyl)isocyanate with an assay of ≥95% (GC). We do not represent this product as USP, BP, or EP grade.
How should (Trimethylsilyl)isocyanate be handled safely?
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This compound is highly flammable and toxic. Handle with extreme care in a well-ventilated area or fume hood, wearing appropriate personal protective equipment including eyeshields, gloves, and a suitable respirator. Avoid contact with oxidising agents and moisture.
Is (Trimethylsilyl)isocyanate a controlled substance?
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The provided data does not indicate that (Trimethylsilyl)isocyanate is a controlled substance.
How is (Trimethylsilyl)isocyanate packed and shipped?
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(Trimethylsilyl)isocyanate is shipped in accordance with UN 2478, Hazard Class 3, Packing Group II regulations for flammable and toxic liquids. Storage is recommended at 2-8°C.
How can I request a quote or sample of (Trimethylsilyl)isocyanate?
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To request a quote or a sample, please contact our sales team through the website or directly via phone or email, providing your specific requirements.
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