(Trimethylsilyl)diazomethane solution
(Trimethylsilyl)diazomethane solution (CAS: 18107-18-1) is a versatile reagent with the molecular formula (CH3)3SiCHN2 and a molecular weight of 114.22 g/mol. Supplied as a 2.0 M solution in hexanes, it is primarily utilised as a reactant in organic synthesis for the preparation of various complex molecules. Its applications span the creation of pharmaceutical intermediates, natural product analogues, and other fine chemicals requiring specific alkylation or derivatisation.
- IUPAC
- (Diazomethyl)trimethylsilane
- Synonyms
- (Diazomethyl)trimethylsilane
Synthesis of Bioactive Molecules
Serves as a key reactant in synthesising macrolactam analogues with enhanced metabolic stability and antibacterial properties, as well as aigialomycin D analogues for potential cancer treatments.
Preparation of Specialised Amino Acids
Facilitates the creation of unnatural alpha-amino acid derivatives containing gem-bisphosphonates through Michael addition reactions, offering novel building blocks for drug discovery.
Development of Enzyme Inhibitors
Used in the synthesis of capped hyaluronan disaccharides and tetrasaccharides that act as potential hyaluronidase substrates, and for creating Stictamides A-C which inhibit matrix metallopeptidase 12 (MMP12).
Organic Synthesis and Derivatisation
A valuable reagent for C-X bond formation and general chemical synthesis, including the preparation of endothelin converting enzyme (ECE) inhibitors and ent-kaurene derivatives with anti-inflammatory activity.
| Molecular weight | 114.22 |
|---|---|
| Linear formula | (CH3)3SiCHN2 |
| Density | 0.718 g/mL at 25 °C |
| Concentration | 2.0 M in hexanes |
| Application | Reactant for preparation of:• Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity1• Aigialomycin D analogues as protein kinase inhibitors for cancer treatment2• Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction3• Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates4• Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity5• Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach6• Ent-kaurene derivatives as anti-inflammatory agents7• Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpo |
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -23 °C / -9.4 °F |
| Transport (UN / ADR) | UN 3383 6.1(3) / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,T+,N |
| Risk statements (R) | 45-11-26-38-39/26-51/53-62-65-67 |
| Safety statements (S) | 53-28-36/37-45-61-62 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (Trimethylsilyl)diazomethane solution used for?
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(Trimethylsilyl)diazomethane solution is a versatile reagent used in organic synthesis for preparing various complex molecules, including bioactive compounds, specialised amino acids, and enzyme inhibitors. It is particularly useful for alkylation and derivatisation reactions.
What is the CAS number and formula for (Trimethylsilyl)diazomethane solution?
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The CAS number is 18107-18-1 and the linear formula is (CH3)3SiCHN2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (Trimethylsilyl)diazomethane solution at a concentration of 2.0 M in hexanes. We do not guarantee specific purity grades beyond this information and do not represent this product as USP, BP, or EP grade.
How should (Trimethylsilyl)diazomethane solution be handled safely?
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This compound is highly flammable, toxic, and can cause serious health effects. Handle with extreme caution in a well-ventilated area, using appropriate personal protective equipment including eyeshields, gloves, and a suitable respirator. Avoid ignition sources and incompatible materials. Refer to the safety data sheet for detailed handling instructions.
How is (Trimethylsilyl)diazomethane solution packaged and shipped?
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Our chemicals are carefully packaged according to international shipping regulations. As a global supplier and exporter, we ensure that shipments of (Trimethylsilyl)diazomethane solution comply with all necessary transport and safety standards.
How can I request a quote or sample?
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To request a quote or a sample of (Trimethylsilyl)diazomethane solution, please contact our sales department through the details provided on our website.
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