(Trimethylsilyl)isothiocyanate
(Trimethylsilyl)isothiocyanate (CAS: 2290-65-5) is an organosilicon compound with the linear formula (CH3)3SiNCS and a molecular weight of 131.27 g/mol. This colourless liquid serves as a valuable reagent in organic synthesis. It is primarily utilised as a derivatizing agent, particularly in the formation of amino acid thiohydantoins, playing a role in analytical and synthetic chemistry processes. Tech Serve Solutions supplies this compound at a 99% assay.
- IUPAC
- Isothiocyanatotrimethylsilane
- Synonyms
- Isothiocyanatotrimethylsilane(Trimethylsilyl)isothiocyanateTrimethylsilyl isothiocyanate
Derivatizing Reagent
Trimethylsilyl isothiocyanate is employed as a derivatizing agent for the synthesis of amino acid thiohydantoins. This application is crucial in analytical techniques where modification of amino acids is required for detection or separation.
Organic Synthesis Building Block
As an isothiocyanate and a silyl compound, it can participate in various organic transformations. It serves as a versatile building block for introducing the isothiocyanate functional group or for silylation reactions in complex molecule construction.
Research and Development
This compound is utilised in chemical research laboratories for exploring new synthetic pathways and developing novel compounds. Its reactivity profile makes it a useful tool for chemists investigating sulphur and silicon chemistry.
| Molecular weight | 131.27 |
|---|---|
| Linear formula | (CH3)3SiNCS |
| Assay | 99% |
| Boiling point | 143 °C(lit.) |
| Density | 0.931 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.482(lit.) |
| Vapour density | >1 (vs air) |
| Melting point | −32.8 °C(lit.) |
| Application | Trimethylsilyl isothiocyanate was used as derivatizing reagent during the synthesis of amino acid thiohydantoins1. |
Hazard statements
- H226Flammable liquid and vapour
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H331Toxic if inhaled
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 29 °C / 84.2 °F |
| Transport (UN / ADR) | UN 1992 3/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 10-23/24/25-36/37/38-42 |
| Safety statements (S) | 23-26-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (Trimethylsilyl)isothiocyanate used for?
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(Trimethylsilyl)isothiocyanate is primarily used as a derivatizing reagent for the synthesis of amino acid thiohydantoins and as a versatile building block in organic synthesis.
What are the CAS number and formula for (Trimethylsilyl)isothiocyanate?
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The CAS number is 2290-65-5 and the linear formula is (CH3)3SiNCS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (Trimethylsilyl)isothiocyanate with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should (Trimethylsilyl)isothiocyanate be handled safely?
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(Trimethylsilyl)isothiocyanate is a flammable liquid and vapour (H226) and is toxic if swallowed (H301), in contact with skin (H311), or if inhaled (H331). It also causes skin (H315) and serious eye irritation (H319), and may cause respiratory irritation (H335) and allergy or asthma symptoms or breathing difficulties if inhaled (H334). Handle with appropriate personal protective equipment, including gloves, eyeshields, and a suitable respirator, in a well-ventilated area.
Is (Trimethylsilyl)isothiocyanate a controlled substance?
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The provided data does not indicate that (Trimethylsilyl)isothiocyanate is a controlled substance.
How is (Trimethylsilyl)isothiocyanate packed and shipped?
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As a global supplier and exporter, Tech Serve Solutions ensures that (Trimethylsilyl)isothiocyanate is packed and shipped in compliance with all relevant regulations for hazardous materials. Specific packaging details are available upon request.
How can I request a quote or sample?
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To request a quote or a sample of (Trimethylsilyl)isothiocyanate, please contact our sales department through the website or by phone, providing your specific requirements.
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