Fmoc-Phe(4-CF3)-OH
Fmoc-Phe(4-CF3)-OH (CAS 247113-86-6) is a trifluoromethylated derivative of phenylalanine, with the empirical formula C25H20F3NO4 and a molecular weight of 455.43 g/mol. Utilised in peptide chemistry and synthesis, this unnatural amino acid derivative is a valuable building block for creating peptides with modified properties. It is typically supplied at ≥97% purity and stored under refrigerated conditions (2-8°C).
- IUPAC
- Fmoc-4-(trifluoromethyl)-L-phenylalanine
Peptide Synthesis
Fmoc-Phe(4-CF3)-OH serves as a crucial building block in solid-phase peptide synthesis (SPPS) and solution-phase synthesis. Its incorporation allows for the introduction of a trifluoromethyl group into peptide sequences, potentially altering their pharmacokinetic and pharmacodynamic properties.
Chemical Biology Research
This unnatural amino acid derivative is employed in chemical biology to create novel peptides with enhanced stability, altered receptor binding affinities, or improved membrane permeability. The trifluoromethyl substituent can act as a stable isostere or a probe for studying biological interactions.
Drug Discovery and Development
Fmoc-Phe(4-CF3)-OH is utilised in the development of new pharmaceutical agents. The trifluoromethyl group can increase lipophilicity and metabolic stability of peptide-based drugs, leading to improved bioavailability and efficacy.
| Molecular weight | 455.43 |
|---|---|
| Empirical formula | C25H20F3NO4 |
| Assay | ≥97% (HPLC) |
| Optical activity | [α]/D -37±2°, c = 1 in DMF |
| Storage temperature | 2-8°C |
| Melting point | 127-130 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Phe(4-CF3)-OH used for?
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Fmoc-Phe(4-CF3)-OH is primarily used as a building block in peptide synthesis, chemical biology research, and drug discovery. It allows for the introduction of a trifluoromethyl group into amino acid sequences, modifying peptide properties such as stability and receptor binding.
What are the CAS number and formula for Fmoc-Phe(4-CF3)-OH?
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The CAS number for Fmoc-Phe(4-CF3)-OH is 247113-86-6, and its empirical formula is C25H20F3NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Phe(4-CF3)-OH with an assay of ≥97% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product specifications.
How should Fmoc-Phe(4-CF3)-OH be handled and stored?
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Handle Fmoc-Phe(4-CF3)-OH with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 respirator filter. Store the chemical at 2-8°C to maintain its stability and integrity.
Is Fmoc-Phe(4-CF3)-OH a controlled substance?
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Based on the provided data, Fmoc-Phe(4-CF3)-OH is not indicated as a controlled substance. However, users should always verify local regulations.
How is Fmoc-Phe(4-CF3)-OH shipped?
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Tech Serve Solutions can pack, ship, and export Fmoc-Phe(4-CF3)-OH globally, adhering to all relevant shipping regulations for chemical compounds.
How can I request a quote or sample for Fmoc-Phe(4-CF3)-OH?
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To request a quote or a sample of Fmoc-Phe(4-CF3)-OH, please contact the Tech Serve Solutions sales team through our website or by phone.
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