Fmoc-Phe(4-F)-OH

CAS 169243-86-1C24H20FNO4Chemical Synthesis

Fmoc-Phe(4-F)-OH (CAS 169243-86-1) is a fluorinated phenylalanine derivative with the molecular formula C24H20FNO4 and a molecular weight of 405.42 g/mol. This compound is a valuable building block in peptide synthesis and chemical biology research. Its applications span the development of novel peptides, peptidomimetics, and modified amino acid-based therapeutics and diagnostics, offering researchers a tool for structural and functional studies.

IUPAC: Fmoc-4-fluoro-L-phenylalanine
Synonyms: Fmoc-4-fluoro-L-phenylalanine

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Fmoc-Phe(4-F)-OH (C24H20FNO4) — chemical structure, CAS 169243-86-1; Chemistry, fine chemical supplied by Tech Serve Solutions

Analytical StandardsAnalytical/ChromatographyChemical BiologyChemical SynthesisFM - FZPeptide ChemistryPhenylalanine Derivatives

01 /Applications

Peptide Synthesis

Used as a protected amino acid building block in solid-phase or solution-phase peptide synthesis, enabling the incorporation of a fluorinated phenylalanine residue into peptide sequences. This is crucial for developing modified peptides with altered pharmacokinetic or pharmacodynamic properties.

Chemical Biology

Applied in the design and synthesis of novel probes and peptidomimetics for studying biological processes and protein-ligand interactions. The fluorine atom can serve as a label for NMR studies or to modulate molecular properties.

Medicinal Chemistry

Serves as a key intermediate in the synthesis of potential pharmaceutical agents. The incorporation of fluorine can enhance metabolic stability, lipophilicity, and binding affinity of drug candidates.

02 /Properties

Molecular weight	405.42
Empirical formula	C24H20FNO4
Assay	≥98.0% (HPLC)
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

169243-86-1

MDL number

MFCD00191197

Beilstein registry

8287377

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-Phe(4-F)-OH used for?

Fmoc-Phe(4-F)-OH is primarily used as a building block in peptide synthesis and in chemical biology research for creating fluorinated peptides, peptidomimetics, and potential drug candidates.

What is the CAS number and formula for Fmoc-Phe(4-F)-OH?

The CAS number is 169243-86-1 and the empirical formula is C24H20FNO4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-Phe(4-F)-OH with a purity of ≥98.0% (HPLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.

How should Fmoc-Phe(4-F)-OH be handled safely?

Handle Fmoc-Phe(4-F)-OH with appropriate personal protective equipment, including eyeshields and gloves. In environments where dust or aerosols may be generated, use a type N95 (US) or type P1 (EN143) respirator filter. Dispose of waste according to local regulations. Note that it has a WGK Germany rating of 3.

How is Fmoc-Phe(4-F)-OH packaged and shipped?

Fmoc-Phe(4-F)-OH is typically stored at 2-8°C. Shipping and export procedures comply with all relevant international and national regulations for chemical substances.