5-Chloro-2-fluoropyridine
5-Chloro-2-fluoropyridine (CAS: 1480-65-5), with a molecular formula of C5H3ClFN and a molecular weight of 131.54 g/mol, is a halogenated heterocyclic compound. It serves as a valuable building block in organic synthesis, particularly for introducing fluorinated pyridine moieties into more complex molecules. Its properties make it useful in the development of pharmaceuticals and agrochemicals.

Pharmaceutical Intermediates
5-Chloro-2-fluoropyridine is employed as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). Its structure allows for versatile functionalization in drug discovery and development processes.
Agrochemical Synthesis
This compound is utilised in the creation of novel agrochemicals, including herbicides and pesticides. The incorporation of fluorine and chlorine atoms can enhance the biological activity and stability of agricultural products.
Materials Science Research
As a fluorinated heterocyclic building block, 5-Chloro-2-fluoropyridine finds application in the research and development of advanced materials. Its unique electronic and structural properties can be exploited in novel polymer or electronic material designs.
Organic Synthesis Reagent
It acts as a versatile reagent in general organic synthesis, enabling the construction of complex molecular architectures. The reactive sites on the pyridine ring allow for diverse chemical transformations.
| Molecular weight | 131.54 |
|---|---|
| Empirical formula | C5H3ClFN |
| Assay | 97% |
| Density | 1.311 g/mL at 25 °C |
| Refractive index | n20/D 1.498 |



Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 52 °C / 125.6 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-22-37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Chloro-2-fluoropyridine primarily used for?
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5-Chloro-2-fluoropyridine is primarily used as a building block and intermediate in organic synthesis, particularly for the development of pharmaceuticals and agrochemicals.
What is the CAS number and formula for 5-Chloro-2-fluoropyridine?
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The CAS number for 5-Chloro-2-fluoropyridine is 1480-65-5, and its empirical formula is C5H3ClFN.
What grade and purity does Tech Serve Solutions supply for 5-Chloro-2-fluoropyridine?
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Tech Serve Solutions supplies 5-Chloro-2-fluoropyridine with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should 5-Chloro-2-fluoropyridine be handled safely?
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5-Chloro-2-fluoropyridine is a flammable liquid and vapour (H226), harmful if swallowed (H302), causes skin irritation (H315), causes serious eye damage (H318), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area.
Is 5-Chloro-2-fluoropyridine exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 5-Chloro-2-fluoropyridine.
How can I request a sample or quote for 5-Chloro-2-fluoropyridine?
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To request a sample or quote for 5-Chloro-2-fluoropyridine, please contact our sales team through the website or by phone.
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