5-Chloro-2-fluorotoluene
5-Chloro-2-fluorotoluene (CAS: 452-66-4), with the molecular formula CH3C6H3(Cl)F and a molar mass of 144.57 g/mol, is a halogenated aromatic hydrocarbon. This compound serves as a valuable building block in organic synthesis, particularly in the development of pharmaceutical intermediates. Its applications include the creation of calcium agonists and topical carbonic anhydrase inhibitors, underscoring its utility in medicinal chemistry research and development.
Synthesis of Calcium Agonists
5-Chloro-2-fluorotoluene is utilized in the synthetic pathways leading to potent and long-lasting calcium agonists. These compounds are of interest in pharmacological research for their potential therapeutic applications.
Development of Carbonic Anhydrase Inhibitors
This chemical intermediate plays a role in the synthesis of topically active carbonic anhydrase inhibitors. Such compounds are investigated for their efficacy in various medical treatments, particularly those affecting ocular pressure.
Organic Synthesis Building Block
As a functionalised toluene derivative, 5-Chloro-2-fluorotoluene acts as a versatile building block in complex organic syntheses. Its halogen substituents offer sites for further chemical modification and derivatization.
| Molecular weight | 144.57 |
|---|---|
| Linear formula | CH3C6H3(Cl)F |
| Assay | 98% |
| Boiling point | 157-159 °C/752 mmHg(lit.) |
| Density | 1.188 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4995(lit.) |
| Application | Employed in the syntheses of potent and long-lasting calcium agonists,1 and topically active carbonic anhydrase inhibitors.2 |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 49 °C / 120.2 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 16-26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Chloro-2-fluorotoluene used for?
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5-Chloro-2-fluorotoluene is primarily used as a building block in organic synthesis, including the preparation of pharmaceutical intermediates such as calcium agonists and carbonic anhydrase inhibitors.
What are the CAS number and molecular formula for 5-Chloro-2-fluorotoluene?
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The CAS number for 5-Chloro-2-fluorotoluene is 452-66-4, and its molecular formula is CH3C6H3(Cl)F.
What grade and purity does Tech Serve Solutions supply for 5-Chloro-2-fluorotoluene?
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Tech Serve Solutions supplies 5-Chloro-2-fluorotoluene with a minimum purity of 98%. This product is supplied for research and laboratory use. Tech Serve Solutions does not represent this product as USP, BP, EP, or any other pharmacopoeial grade.
How should 5-Chloro-2-fluorotoluene be handled safely?
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5-Chloro-2-fluorotoluene is a flammable liquid and vapour (H226). It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including safety goggles, gloves, and respiratory protection, should be used. Handle in a well-ventilated area.
Is 5-Chloro-2-fluorotoluene a controlled substance?
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Based on the provided data, 5-Chloro-2-fluorotoluene is not indicated as a controlled substance. However, users should always verify local regulations.
How is 5-Chloro-2-fluorotoluene packed and shipped?
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5-Chloro-2-fluorotoluene is typically packed in compliance with transport regulations for flammable liquids. It is UN 1993C 3 / PGIII classified. Tech Serve Solutions exports globally, adhering to all relevant shipping guidelines.
How can I request a quote or sample for 5-Chloro-2-fluorotoluene?
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To request a quote or a sample of 5-Chloro-2-fluorotoluene, please contact the Tech Serve Solutions sales team through our website or designated contact channels, providing your specific requirements.
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