5-Chloro-2-fluorophenylboronic acid
5-Chloro-2-fluorophenylboronic acid (CAS: 352535-83-2) is a valuable organoboron compound with the chemical formula ClC6H3(F)B(OH)2 and a molecular weight of 174.37 g/mol. This disubstituted aryl boronic acid serves as a key building block in organic synthesis, particularly in cross-coupling reactions. It is employed in the preparation of complex molecules relevant to medicinal chemistry and materials science.
Suzuki Cross-Coupling Reactions
5-Chloro-2-fluorophenylboronic acid is a versatile reactant in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds for the synthesis of diverse organic structures.
Medicinal Chemistry Intermediates
This compound is instrumental in the synthesis of molecules with potential biological activity, including the preparation of biaryl amides investigated for muscarinic acetylcholine receptor subtype M1 agonistic activity.
Development of Kinase Inhibitors
It finds application in synthetic pathways leading to novel inhibitors of kinesin spindle protein, a target in cancer research and therapy.
GABA Receptor Modulators
The boronic acid derivative is utilized in the preparation of GABA α2/3 agonists, which are of interest for their potential therapeutic applications in neurological disorders.
| Molecular weight | 174.37 |
|---|---|
| Linear formula | ClC6H3(F)B(OH)2 |
| Application | Reactant involved in:• Suzuki cross-coupling reactions1• Synthesis of biaryl amides with muscarinic acetylcholine receptor subtype M1 agonistic activity2• Synthesis of kinesin spindle protein inhibitors3• GABA α2/3 agonist preparation4 |
| Melting point | 122-127 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Chloro-2-fluorophenylboronic acid used for?
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5-Chloro-2-fluorophenylboronic acid is used as a reactant in Suzuki cross-coupling reactions and in the synthesis of various complex organic molecules, including intermediates for pharmaceuticals like biaryl amides and kinesin spindle protein inhibitors, as well as GABA receptor modulators.
What is the CAS number and chemical formula for 5-Chloro-2-fluorophenylboronic acid?
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The CAS number for 5-Chloro-2-fluorophenylboronic acid is 352535-83-2, and its linear chemical formula is ClC6H3(F)B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product for research and chemical synthesis. The specific grade and purity are available upon request. We do not represent this product as USP, BP, or EP grade.
How should 5-Chloro-2-fluorophenylboronic acid be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Please consult the Safety Data Sheet for comprehensive handling and safety information.
How is 5-Chloro-2-fluorophenylboronic acid shipped?
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Tech Serve Solutions exports fine chemicals globally. Packaging and shipping methods adhere to international regulations for chemical transport. Please contact us for specific shipping inquiries.
How can I request a sample or quote for 5-Chloro-2-fluorophenylboronic acid?
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To request a sample or obtain a quote for 5-Chloro-2-fluorophenylboronic acid, please contact our sales team through the website or by phone.
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