5-Chloro-2-fluorobenzonitrile

CAS 57381-34-7ClC6H3(F)CNChemical Synthesis

5-Chloro-2-fluorobenzonitrile (CAS: 57381-34-7, Formula: ClC6H3(F)CN, Molar Mass: 155.56 g/mol) is a key organic intermediate. This halogenated aromatic nitrile serves as a versatile building block in complex organic synthesis. It is particularly valuable in the development of novel pharmaceuticals and agrochemicals, owing to the presence of reactive chlorine, fluorine, and nitrile functionalities. Available from Tech Serve Solutions at 97% purity.

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5-Chloro-2-fluorobenzonitrile (ClC6H3(F)CN) — chemical structure, CAS 57381-34-7; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksC6 to C7Chemical SynthesisCyanides/NitrilesFluorinated Building BlocksNitrogen CompoundsOrganic Building Blocks

01 /Applications

Pharmaceutical Intermediate

Utilised in the synthesis of active pharmaceutical ingredients (APIs) and drug discovery research. Its structural features facilitate the introduction of specific pharmacophores.

Agrochemical Synthesis

Acts as a precursor for the development of new pesticides, herbicides, and fungicides. The halogen substituents can impart desirable biological activity.

Materials Science

Explored for its potential in the creation of advanced materials and specialty polymers. The nitrile group offers possibilities for further functionalisation.

Organic Synthesis Building Block

A valuable synthon for introducing a chloro-fluoro-benzonitrile moiety into target molecules in multi-step synthetic routes.

02 /Properties

Molecular weight	155.56
Linear formula	ClC6H3(F)CN
Assay	97%
Melting point	67-70 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	20/21/22
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

57381-34-7

MDL number

MFCD01631434

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 5-Chloro-2-fluorobenzonitrile used for?

5-Chloro-2-fluorobenzonitrile is primarily used as a building block in organic synthesis, particularly for pharmaceuticals and agrochemicals.

What are the CAS number and chemical formula for 5-Chloro-2-fluorobenzonitrile?

The CAS number is 57381-34-7 and the chemical formula is ClC6H3(F)CN.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 5-Chloro-2-fluorobenzonitrile with an assay of 97%. We do not represent it as USP, BP, or EP grade.

How should 5-Chloro-2-fluorobenzonitrile be handled safely?

Handle with appropriate personal protective equipment including a dust mask (N95), eyeshields, and gloves. Avoid inhalation, ingestion, and skin contact. Refer to the Safety Data Sheet for full details.

Is 5-Chloro-2-fluorobenzonitrile subject to any special shipping regulations?

As per the provided safety data, 5-Chloro-2-fluorobenzonitrile is classified with hazard codes Xn and poses H302, H312, H332 hazards. It is shipped according to relevant regulations for hazardous materials.