3-(2-Thienyl)-L-alanine
3-(2-Thienyl)-L-alanine (CAS: 22951-96-8, Formula: C7H9NO2S, MW: 171.22) is an unnatural amino acid derivative featuring a thiophene ring. This chiral compound, specifically the L-enantiomer, serves as a valuable building block in chemical synthesis and peptide chemistry. It is employed in research settings for the development of novel peptides and biologically active molecules, contributing to advancements in chemical biology.
- IUPAC
- (S)-α-Amino-2-thiophenepropionic acid,(S)-2-Amino-3-(2-thienyl)propionic acid
- Synonyms
- (S)-α-Amino-2-thiophenepropionic acid(S)-2-Amino-3-(2-thienyl)propionic acid

Peptide Synthesis
Incorporation into peptide chains to create modified peptides with altered structural or functional properties. Used as a non-canonical amino acid to probe peptide conformation and biological activity.
Chemical Biology Research
As a tool compound for investigating biological pathways and protein interactions. Its unique structure allows for the study of specific molecular recognition events.
Organic Synthesis
Serves as a chiral synthon for the construction of complex organic molecules. The thienyl group and amino acid functionality offer versatile reaction sites.
Drug Discovery and Development
Investigated for its potential role in the development of new therapeutic agents. Its structure may be incorporated into lead compounds for medicinal chemistry programs.
| Molecular weight | 171.22 |
|---|---|
| Empirical formula | C7H9NO2S |
| Assay | ≥98.0% (TLC) |
| Optical activity | [α]20/D −31.5±1°, c = 1% in H2O |
| Melting point | 255-263 °C (dec.)(lit.)~260 °C (dec.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(2-Thienyl)-L-alanine used for?
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3-(2-Thienyl)-L-alanine is primarily used in peptide synthesis, chemical biology research, organic synthesis, and drug discovery. It acts as an unnatural amino acid building block for creating modified peptides and complex organic molecules.
What are the CAS number and formula for 3-(2-Thienyl)-L-alanine?
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The CAS number for 3-(2-Thienyl)-L-alanine is 22951-96-8, and its empirical formula is C7H9NO2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-(2-Thienyl)-L-alanine with an assay of ≥98.0% (TLC). We do not represent this product as USP, EP, BP, or any other pharmacopoeia grade.
What are the safety and handling considerations for this product?
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This compound is a Warning substance (GHS07) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). It requires the use of a dust mask (N95), eyeshields, and gloves for safe handling.
How is 3-(2-Thienyl)-L-alanine packed and shipped?
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Products are carefully packed according to international shipping regulations and are exported globally by Tech Serve Solutions.
How can I request a sample or quote for 3-(2-Thienyl)-L-alanine?
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To request a sample or a quote, please contact our sales team through the website or by phone. Please reference the product name and CAS number (22951-96-8).
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