Fmoc-D-Trp-OH
Fmoc-D-Trp-OH (CAS: 86123-11-7) is a protected D-tryptophan derivative with the molecular formula C26H22N2O4. Its N-terminus is protected by the Fmoc group, commonly used in solid-phase peptide synthesis to facilitate controlled chain elongation. This compound serves as a crucial building block in the synthesis of peptides containing the unnatural D-tryptophan enantiomer, enabling the creation of peptides with modified structures and potentially enhanced biological properties. Available from Tech Serve Solutions with a minimum assay of 98.0%.
- IUPAC
- Nα-(9-Fluorenylmethoxycarbonyl)-D-tryptophan,Fmoc-D-tryptophan
- Synonyms
- Nα-(9-Fluorenylmethoxycarbonyl)-D-tryptophanFmoc-D-tryptophan
Peptide Synthesis
Fmoc-D-Trp-OH is a key reagent in solid-phase peptide synthesis (SPPS) utilising Fmoc chemistry. It allows for the incorporation of D-tryptophan into peptide sequences, enabling the exploration of conformational stability and biological activity.
Chemical Biology Research
As a protected unnatural amino acid, it is employed in the design and synthesis of peptides for chemical biology studies. This includes creating peptidomimetics or probes to investigate protein-protein interactions and enzymatic pathways.
Pharmaceutical Intermediate
This compound can function as an intermediate in the synthesis of complex pharmaceutical agents or drug candidates that incorporate modified tryptophan residues, influencing their pharmacokinetic or pharmacodynamic profiles.
Material Science
Peptides synthesised using Fmoc-D-Trp-OH can be explored for their self-assembly properties or incorporation into novel biomaterials, leveraging the unique structural features introduced by the D-enantiomer.
| Molecular weight | 426.46 |
|---|---|
| Empirical formula | C26H22N2O4 |
| Assay | ≥98.0% |
| Storage temperature | 2-8°C |
| Melting point | 182-185 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-Trp-OH used for?
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Fmoc-D-Trp-OH is primarily used as a building block in solid-phase peptide synthesis (SPPS) to incorporate the unnatural D-tryptophan enantiomer into peptide sequences, for applications in chemical biology, pharmaceutical research, and material science.
What is the CAS number and molecular formula for Fmoc-D-Trp-OH?
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The CAS number is 86123-11-7, and the molecular formula is C26H22N2O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-D-Trp-OH with a minimum assay of 98.0%. This product is intended for research and laboratory use; TSS does not represent it as USP, BP, EP, or pharmacopoeia grade.
How should Fmoc-D-Trp-OH be handled and stored?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves, and a suitable respirator filter. Store at 2-8°C to maintain stability.
Is Fmoc-D-Trp-OH a controlled substance?
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The provided data does not indicate that Fmoc-D-Trp-OH is a controlled substance.
How is Fmoc-D-Trp-OH packed, shipped, and exported?
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Fmoc-D-Trp-OH is carefully packed to ensure integrity during transit. As a global supplier, Tech Serve Solutions has extensive experience in exporting chemicals worldwide, adhering to all necessary regulations.
How can I request a sample or quote for Fmoc-D-Trp-OH?
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Please contact our sales team through the website or by phone to request a sample or a detailed quotation for Fmoc-D-Trp-OH.
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