Fmoc-D-Ser-OH
Fmoc-D-Ser-OH (CAS: 116861-26-8), a derivative of the non-proteinogenic amino acid D-serine, has the molecular formula C18H17NO5 and a molecular weight of 327.33 g/mol. This compound is widely employed in solid-phase peptide synthesis (SPPS) due to the base-labile nature of the Fmoc protecting group. It serves as a crucial building block for incorporating D-serine residues into peptides, enabling the study of their structure, function, and biological activity in various research applications.
- IUPAC
- Fmoc-D-serine
- Synonyms
- Fmoc-D-serine
Peptide Synthesis
Fmoc-D-Ser-OH is a key reagent in solid-phase peptide synthesis (SPPS) for the controlled incorporation of D-serine residues. Its Fmoc protecting group facilitates efficient coupling cycles, making it invaluable for constructing peptides with unnatural amino acids.
Biochemical Research
This compound is utilised in biochemical and chemical biology research to synthesise peptides containing D-serine. Such peptides can be employed to investigate enzyme mechanisms, protein folding, and the biological roles of modified amino acids.
Analytical Standards
Fmoc-D-Ser-OH serves as a reference standard in analytical chemistry, particularly for chromatography and mass spectrometry. It aids in the identification and quantification of related compounds in complex mixtures.
Drug Discovery
In drug discovery programs, Fmoc-D-Ser-OH is used to create novel peptide-based therapeutics. The inclusion of D-amino acids can enhance peptide stability against enzymatic degradation and modulate pharmacokinetic properties.
| Molecular weight | 327.33 |
|---|---|
| Empirical formula | C18H17NO5 |
| Assay | ≥98.0% |
| Optical activity | [α]20/D +12.5±1.0°, c = 1% in DMF |
| Storage temperature | 2-8°C |
| Melting point | 108-112 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-Ser-OH used for?
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Fmoc-D-Ser-OH is primarily used as a building block in solid-phase peptide synthesis (SPPS) to incorporate the unnatural amino acid D-serine into peptide chains. It is also utilised in biochemical research, drug discovery, and as an analytical standard.
What are the CAS number and molecular formula for Fmoc-D-Ser-OH?
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The CAS number for Fmoc-D-Ser-OH is 116861-26-8, and its molecular formula is C18H17NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-D-Ser-OH with an assay of ≥98.0%. TSS does not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should Fmoc-D-Ser-OH be handled and stored?
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Fmoc-D-Ser-OH should be stored at 2-8°C. When handling, wear appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. It is classified under WGK Germany 3.
Is Fmoc-D-Ser-OH a controlled substance?
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The provided data does not indicate that Fmoc-D-Ser-OH is a controlled substance.
How are Tech Serve Solutions' chemicals typically shipped?
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Tech Serve Solutions is a global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, shipping products worldwide according to international regulations.
How can I request a sample or quote for Fmoc-D-Ser-OH?
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To request a sample or a quote for Fmoc-D-Ser-OH, please contact the Tech Serve Solutions sales team through our website or direct contact details.
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