Fmoc-D-Ser(tBu)-OH

CAS 128107-47-1C22H25NO5Chemical Synthesis

Fmoc-D-Ser(tBu)-OH (CAS: 128107-47-1) is a protected D-amino acid derivative with the molecular formula C22H25NO5 and a molecular weight of 383.44 g/mol. This compound features the Fmoc protecting group on the amine and a tert-butyl protecting group on the serine hydroxyl. It is a valuable building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of D-serine residues into peptide chains. It is also used in chemical biology and general chemical synthesis.

IUPAC: Fmoc-O-tert-butyl-D-serine
Synonyms: Fmoc-O-tert-butyl-D-serine

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Fmoc-D-Ser(tBu)-OH (C22H25NO5) — chemical structure, CAS 128107-47-1; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesChemical BiologyChemical SynthesisPeptide ChemistrySerine

01 /Applications

Peptide Synthesis

Fmoc-D-Ser(tBu)-OH serves as a crucial building block in solid-phase peptide synthesis, allowing for the stereospecific incorporation of D-serine into peptide sequences. The tert-butyl group protects the hydroxyl functionality during coupling reactions.

Chemical Biology Research

This compound is employed in chemical biology for the synthesis of modified peptides and peptidomimetics. Its use facilitates studies on protein structure-function relationships and the development of novel bioactive molecules.

Organic Synthesis

As a versatile protected amino acid, Fmoc-D-Ser(tBu)-OH is utilised in complex organic synthesis routes. It enables chemists to introduce specific structural motifs and chirality into target molecules.

02 /Properties

Molecular weight	383.44
Empirical formula	C22H25NO5
Assay	≥98.0% (TLC)
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

128107-47-1

MDL number

MFCD00077071

Beilstein registry

5309984

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-D-Ser(tBu)-OH used for?

Fmoc-D-Ser(tBu)-OH is primarily used as a protected building block in solid-phase peptide synthesis (SPPS) for incorporating D-serine residues and in chemical biology and organic synthesis research.

What are the CAS number and formula for Fmoc-D-Ser(tBu)-OH?

The CAS number for Fmoc-D-Ser(tBu)-OH is 128107-47-1, and its empirical formula is C22H25NO5.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-D-Ser(tBu)-OH with a purity of ≥98.0% (TLC). This product is supplied for research and development purposes and is not represented as USP, BP, EP, or other pharmacopoeial grades.

What are the safety and handling recommendations for Fmoc-D-Ser(tBu)-OH?

Appropriate personal protective equipment, including eyeshields and gloves, should be worn. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified under WGK-2 in Germany, indicating it is hazardous to water.

How is Fmoc-D-Ser(tBu)-OH stored and shipped?

Fmoc-D-Ser(tBu)-OH should be stored at 2-8°C. Tech Serve Solutions ensures proper packaging and handling for domestic and international export, adhering to all relevant shipping regulations.

How can I request a quote or sample for Fmoc-D-Ser(tBu)-OH?

To request a quote or sample of Fmoc-D-Ser(tBu)-OH, please contact the Tech Serve Solutions sales team through our website or by phone, providing your specific requirements.