Fmoc-D-Thr(tBu)-OH
Fmoc-D-Thr(tBu)-OH (CAS: 138797-71-4, C23H27NO5) is a protected D-threonine derivative used in peptide synthesis. This compound features an Fmoc protecting group on the amine and a tert-butyl protecting group on the hydroxyl side chain, facilitating controlled peptide chain elongation. Its application is primarily in solid-phase peptide synthesis (SPPS) and solution-phase synthesis, enabling the incorporation of D-threonine residues into peptides and peptidomimetics for research and development.
- IUPAC
- Fmoc-O-tert-butyl-D-threonine
Peptide Synthesis
Utilised as a building block in solid-phase and solution-phase peptide synthesis, allowing for the regioselective introduction of Fmoc-protected D-threonine with side-chain protection.
Organic Synthesis
Serves as a chiral intermediate in the synthesis of complex organic molecules, particularly those containing amino acid functionalities. The protecting groups allow for selective chemical transformations.
Chemical Biology Research
Incorporated into peptides designed for studying biological processes, protein structure-function relationships, and developing peptide-based therapeutics.
| Molecular weight | 397.46 |
|---|---|
| Empirical formula | C23H27NO5 |
| Assay | ≥98.0% (TLC) |
| Optical activity | [α]20/D −15±1.5°, c = 1% in ethyl acetate |
| Storage temperature | 2-8°C |
| Melting point | ~130 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-Thr(tBu)-OH used for?
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Fmoc-D-Thr(tBu)-OH is used as a protected amino acid building block in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS), for incorporating D-threonine residues into peptide chains.
What is the CAS number and formula for Fmoc-D-Thr(tBu)-OH?
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The CAS number is 138797-71-4 and the empirical formula is C23H27NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-D-Thr(tBu)-OH with an assay of ≥98.0% (TLC). We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated.
How should Fmoc-D-Thr(tBu)-OH be handled and stored?
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Handle with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 respirator filter. Store at 2-8°C to maintain product integrity. Refer to the Safety Data Sheet for comprehensive handling information. It is classified under WGK Germany 3.
How is Fmoc-D-Thr(tBu)-OH packed and exported?
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Fmoc-D-Thr(tBu)-OH is carefully packed to ensure stability during transport and is exported globally by Tech Serve Solutions, adhering to all necessary regulations for chemical export.
How can I request a sample or quote for Fmoc-D-Thr(tBu)-OH?
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To request a sample or a quote, please contact our sales team through the website or by phone, providing the product name and CAS number.
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