3,5-Difluorosalicylaldehyde
3,5-Difluorosalicylaldehyde (CAS: 63954-77-8), with the molecular formula F₂C₆H₂(OH)CHO and a molecular weight of 158.10, is a fluorinated aromatic aldehyde. This chemical serves as a valuable building block in organic synthesis, particularly for introducing difluorosalicyl moiety into more complex molecules. It is predominantly utilised in research and development settings for the creation of novel compounds, contributing to advancements in material science and medicinal chemistry.
- Synonyms
- F2C6H2(OH)CHO

Organic Synthesis Intermediate
3,5-Difluorosalicylaldehyde is a key intermediate for synthesising a wide range of complex organic molecules. Its reactive aldehyde and hydroxyl groups, along with the fluorine substituents, make it ideal for various chemical transformations.
Fluorinated Compound Development
This compound is instrumental in the development of novel fluorinated organic materials. The incorporation of fluorine atoms can significantly alter a molecule's properties, such as lipophilicity, metabolic stability, and binding affinity.
Research and Development
Primarily used in laboratory settings, 3,5-Difluorosalicylaldehyde facilitates research into new pharmaceuticals, agrochemicals, and advanced materials. It enables chemists to explore structure-activity relationships and develop innovative chemical entities.
| Molecular weight | 158.10 |
|---|---|
| Linear formula | F2C6H2(OH)CHO |
| Assay | 97% |
| Melting point | 87-91 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,5-Difluorosalicylaldehyde used for?
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3,5-Difluorosalicylaldehyde is used as a building block in organic synthesis, particularly for developing fluorinated compounds in research and development for potential applications in material science and medicinal chemistry.
What is the CAS number and chemical formula for 3,5-Difluorosalicylaldehyde?
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The CAS number is 63954-77-8 and the linear chemical formula is F₂C₆H₂(OH)CHO.
What grade and purity does Tech Serve Solutions supply for 3,5-Difluorosalicylaldehyde?
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Tech Serve Solutions supplies 3,5-Difluorosalicylaldehyde with an assay of 97%. We do not represent this product as USP, EP, BP, or any other pharmacopoeia grade unless explicitly stated.
How should 3,5-Difluorosalicylaldehyde be handled safely?
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3,5-Difluorosalicylaldehyde is a Warning substance that causes skin irritation, serious eye irritation, and may cause respiratory irritation. Handle with appropriate personal protective equipment, including eyeshields, gloves, and a dust mask (type N95 or equivalent), in a well-ventilated area.
How is 3,5-Difluorosalicylaldehyde packaged and exported?
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3,5-Difluorosalicylaldehyde is carefully packaged to ensure product integrity during transit and is available for global export by Tech Serve Solutions.
How can I request a sample or quote for 3,5-Difluorosalicylaldehyde?
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To request a sample or a quote for 3,5-Difluorosalicylaldehyde, please contact our sales team through the website or by phone.
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