Fmoc-D-Phe(3-F)-OH
Fmoc-D-Phe(3-F)-OH (CAS: 198545-72-1) is a fluorinated unnatural amino acid derivative with the molecular formula C24H20FNO4 and a molecular weight of 405.42 g/mol. This compound is a valuable building block in peptide synthesis and chemical biology research. Its unique structure, incorporating a fluorine atom on the phenylalanine ring and the Fmoc protecting group, allows for specific modifications in peptide chains, influencing their properties and biological activity. It is supplied for research purposes.
- IUPAC
- Fmoc-3-fluoro-D-phenylalanine
Peptide Synthesis
Fmoc-D-Phe(3-F)-OH serves as a specialised building block in solid-phase and solution-phase peptide synthesis. The incorporation of the 3-fluorophenylalanine moiety allows for the introduction of unique structural and electronic properties into peptides.
Chemical Biology Research
This unnatural amino acid derivative is employed in chemical biology to create modified peptides with altered conformational stability, binding affinities, or metabolic resistance. The fluorine atom can also serve as a probe in biophysical studies.
Medicinal Chemistry
Fluorinated amino acids are often incorporated into potential drug candidates to enhance properties such as lipophilicity, metabolic stability, and receptor binding. Fmoc-D-Phe(3-F)-OH provides a means to introduce such modifications into peptide-based therapeutics.
Drug Discovery
It is utilised in the design and synthesis of novel peptidomimetics and peptide conjugates aimed at exploring new therapeutic avenues. The fluorine substitution can fine-tune pharmacokinetic and pharmacodynamic profiles.
| Molecular weight | 405.42 |
|---|---|
| Empirical formula | C24H20FNO4 |
| Assay | ≥96.0% (HPLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-Phe(3-F)-OH used for?
+
Fmoc-D-Phe(3-F)-OH is used as a specialised building block in peptide synthesis, chemical biology research, medicinal chemistry, and drug discovery, particularly for introducing fluorinated unnatural amino acid residues into peptides.
What is the CAS number and molecular formula for Fmoc-D-Phe(3-F)-OH?
+
The CAS number is 198545-72-1, and the molecular formula is C24H20FNO4.
What grade and purity does Tech Serve Solutions supply for Fmoc-D-Phe(3-F)-OH?
+
Tech Serve Solutions supplies Fmoc-D-Phe(3-F)-OH with an assay of ≥96.0% (HPLC). TSS does not represent this product as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling recommendations for Fmoc-D-Phe(3-F)-OH?
+
Recommended personal protective equipment includes eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. The compound is classified under WGK Germany 3, indicating a high hazard to water.
How is Fmoc-D-Phe(3-F)-OH typically stored and shipped?
+
Fmoc-D-Phe(3-F)-OH should be stored at 2-8°C. Tech Serve Solutions exports chemicals globally, adhering to all necessary shipping regulations for research chemicals.
How can I request a quote or sample for Fmoc-D-Phe(3-F)-OH?
+
To request a quote or a sample of Fmoc-D-Phe(3-F)-OH, please contact our sales team through the website or by telephone. Please specify the quantity required.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis