Fmoc-D-Phe(3-Me)-OH
Fmoc-D-Phe(3-Me)-OH (CAS: 352351-64-5), with the molecular formula C25H23NO4 and a molecular weight of 401.45, is a specialized unnatural amino acid derivative. It is a crucial building block in peptide synthesis, particularly for creating modified peptides with specific structural or functional properties. Its applications span chemical biology and advanced chemical synthesis, where precise molecular modifications are required. Supplied by TSS, it ensures high purity for demanding research applications.
- IUPAC
- Fmoc-3-methyl-D-phenylalanine
- Synonyms
- Fmoc-3-methyl-D-phenylalanine

Peptide Synthesis
Fmoc-D-Phe(3-Me)-OH serves as a key building block for solid-phase and solution-phase peptide synthesis. Its incorporation allows for the creation of peptides with unnatural structures, potentially enhancing stability or modulating biological activity.
Chemical Biology Research
This unnatural amino acid derivative is utilised in chemical biology to probe protein function and structure. Its modified phenylalanine core can be used to introduce specific labels or to study interactions within biological systems.
Drug Discovery and Development
In the pharmaceutical sector, Fmoc-D-Phe(3-Me)-OH is employed in the design and synthesis of novel peptide-based therapeutics. It enables the development of drug candidates with improved pharmacokinetic profiles or targeted efficacy.
Chemical Synthesis
Beyond peptide applications, it functions as a valuable intermediate in complex organic synthesis pathways. Its unique structure can be leveraged to construct intricate molecular architectures.
| Molecular weight | 401.45 |
|---|---|
| Empirical formula | C25H23NO4 |
| Assay | ≥98.0% (HPLC) |
| Storage temperature | 2-8°C |
| Impurities tested | ~10% isopropanol |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-Phe(3-Me)-OH used for?
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Fmoc-D-Phe(3-Me)-OH is primarily used as a building block in peptide synthesis, chemical biology research, and drug discovery due to its nature as an unnatural amino acid derivative.
What are the CAS number and formula for Fmoc-D-Phe(3-Me)-OH?
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The CAS number for Fmoc-D-Phe(3-Me)-OH is 352351-64-5, and its empirical formula is C25H23NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-D-Phe(3-Me)-OH with an assay of ≥98.0% (HPLC). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Fmoc-D-Phe(3-Me)-OH be handled and stored?
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Handle Fmoc-D-Phe(3-Me)-OH with appropriate personal protective equipment, including eyeshields, gloves, and a P1/N95 respirator. Store the chemical at 2-8°C to maintain its stability.
Is Fmoc-D-Phe(3-Me)-OH a controlled substance?
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The provided data does not indicate that Fmoc-D-Phe(3-Me)-OH is a controlled substance.
How is Fmoc-D-Phe(3-Me)-OH packed, shipped, and exported?
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Fmoc-D-Phe(3-Me)-OH is carefully packed to ensure stability during transit and is available for global export by Tech Serve Solutions.
How can I request a sample or quote for Fmoc-D-Phe(3-Me)-OH?
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To request a sample or a quotation for Fmoc-D-Phe(3-Me)-OH, please contact the Tech Serve Solutions sales team through our website or by phone.
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