Fmoc-D-Phe(4-CF3)-OH

CAS 238742-88-6C25H20F3NO4Chemical Synthesis

Fmoc-D-Phe(4-CF3)-OH (CAS: 238742-88-6) is a trifluoromethylated phenylalanine derivative with the molecular formula C25H20F3NO4. This unnatural amino acid derivative is primarily utilised in chemical synthesis and peptide chemistry. Its unique structure, featuring a trifluoromethyl group on the phenyl ring and Fmoc protection, makes it valuable for introducing specific properties into peptide chains during research and development in chemical biology.

IUPAC: Fmoc-4-(trifluoromethyl)-D-phenylalanine

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Fmoc-D-Phe(4-CF3)-OH (C25H20F3NO4) — chemical structure, CAS 238742-88-6; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical BiologyChemical SynthesisPeptide ChemistryPhenylalanine Derivatives

01 /Applications

Peptide Synthesis

Fmoc-D-Phe(4-CF3)-OH serves as a crucial building block in solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis. It allows for the incorporation of a non-natural, trifluoromethylated D-phenylalanine residue, enabling the creation of peptides with altered conformational stability, lipophilicity, and metabolic resistance.

Chemical Biology Research

This compound is employed in chemical biology to design and synthesise novel peptides for studying protein-protein interactions, enzyme inhibition, and receptor binding. The trifluoromethyl group can act as a useful spectroscopic probe or enhance binding affinity due to its electronic properties.

Drug Discovery and Development

As an unnatural amino acid derivative, Fmoc-D-Phe(4-CF3)-OH is a valuable tool in medicinal chemistry for generating peptide-based therapeutics. Modifications with such building blocks can lead to improved pharmacokinetic profiles and therapeutic efficacy of drug candidates.

Organic Synthesis

Beyond peptide chemistry, this derivative can be used in various organic synthesis strategies where a chiral trifluoromethyl-substituted aromatic moiety is required. Its protected amine and carboxylic acid functionalities offer versatile reactivity.

02 /Properties

Molecular weight	455.43
Empirical formula	C25H20F3NO4
Assay	≥98.0%
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

238742-88-6

MDL number

MFCD00797582

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-D-Phe(4-CF3)-OH used for?

Fmoc-D-Phe(4-CF3)-OH is used as a building block in peptide synthesis, chemical biology research, and drug discovery to incorporate a trifluoromethylated D-phenylalanine residue into peptides and other molecules, potentially enhancing stability and modulating properties.

What are the CAS number and formula for Fmoc-D-Phe(4-CF3)-OH?

The CAS number is 238742-88-6 and the empirical formula is C25H20F3NO4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-D-Phe(4-CF3)-OH with an assay of ≥98.0%. This product is suitable for research and chemical synthesis purposes; TSS does not represent it as USP, BP, EP, or other pharmacopoeial grades.

What are the safety and handling precautions for Fmoc-D-Phe(4-CF3)-OH?

Handle with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Observe appropriate laboratory safety protocols, as indicated by the WGK Germany classification of 3.

How is Fmoc-D-Phe(4-CF3)-OH stored and shipped?

Recommended storage temperature is 2-8°C. TSS ensures proper packaging and handling for export, adhering to all relevant shipping regulations for chemical compounds.

How can I request a sample or quote for Fmoc-D-Phe(4-CF3)-OH?

To request a sample or quote, please use the contact form on our website or contact our sales department directly, providing the product name and CAS number (238742-88-6).