Fmoc-D-Phe(3-CF3)-OH
Fmoc-D-Phe(3-CF3)-OH (CAS: 205526-28-9), with the empirical formula C25H20F3NO4 and molecular weight 455.43, is a specialised unnatural amino acid derivative. Utilised primarily in peptide chemistry and chemical synthesis, this compound offers unique structural properties due to its trifluoromethyl substitution. It is an essential building block for researchers and chemists developing novel peptides and complex organic molecules.
- IUPAC
- Fmoc-3-(trifluoromethyl)-D-phenylalanine
Peptide Synthesis
Fmoc-D-Phe(3-CF3)-OH serves as a crucial building block in solid-phase peptide synthesis (SPPS) and solution-phase synthesis. Its incorporation allows for the introduction of a non-natural amino acid residue with specific steric and electronic properties into peptide sequences.
Chemical Synthesis
This fluorinated phenylalanine derivative is employed in organic synthesis for the construction of complex molecules. The trifluoromethyl group can influence lipophilicity, metabolic stability, and binding interactions in target compounds.
Drug Discovery and Development
Researchers utilise unnatural amino acids like Fmoc-D-Phe(3-CF3)-OH in medicinal chemistry to design peptidomimetics and small molecules with improved pharmacokinetic profiles or enhanced biological activity.
Chemical Biology Research
The unique properties of this compound make it valuable for studying protein-ligand interactions, developing molecular probes, and investigating structure-activity relationships in biological systems.
| Molecular weight | 455.43 |
|---|---|
| Empirical formula | C25H20F3NO4 |
| Assay | ≥98.0% |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-Phe(3-CF3)-OH primarily used for?
+
Fmoc-D-Phe(3-CF3)-OH is primarily used in peptide synthesis, chemical synthesis, drug discovery, and chemical biology research as a specialised building block, particularly for introducing trifluoromethyl-substituted phenylalanine residues into peptides and other organic molecules.
What is the CAS number and empirical formula for Fmoc-D-Phe(3-CF3)-OH?
+
The CAS number for Fmoc-D-Phe(3-CF3)-OH is 205526-28-9, and its empirical formula is C25H20F3NO4.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Fmoc-D-Phe(3-CF3)-OH with an assay of ≥98.0%. This product is intended for research and synthesis purposes and is not represented as USP, BP, EP, or pharmaceutical grade.
How should Fmoc-D-Phe(3-CF3)-OH be stored and handled?
+
Fmoc-D-Phe(3-CF3)-OH should be stored at 2-8°C. When handling, it is essential to use appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter, as indicated by its safety data.
Is this chemical a controlled substance?
+
The provided data does not indicate that Fmoc-D-Phe(3-CF3)-OH is a controlled substance. Always consult local regulations for specific chemical handling and reporting requirements.
How is this chemical packed and shipped?
+
Tech Serve Solutions packs and ships chemicals with care to ensure product integrity during transit. Standard packaging suitable for research chemicals is used. Export services are available.
How can I request a sample or a quote for Fmoc-D-Phe(3-CF3)-OH?
+
To request a sample or a quote for Fmoc-D-Phe(3-CF3)-OH, please use the contact form on our website or contact our sales department directly.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis