Fmoc-D-Phe(4-CN)-OH
Fmoc-D-Phe(4-CN)-OH (CAS: 205526-34-7) is a chemically synthesised protected amino acid derivative with the molecular formula C25H20N2O4 and a molecular weight of 412.44 g/mol. This compound serves as a valuable building block in organic synthesis, particularly within the fields of chemical biology and peptide chemistry. Its structure, featuring a cyano-substituted phenylalanine moiety protected by an Fmoc group, allows for controlled incorporation into complex molecular architectures.
- IUPAC
- Fmoc-4-cyano-D-phenylalanine,Fmoc-D-4-cyanophenylalanine

Peptide Synthesis
Fmoc-D-Phe(4-CN)-OH is utilised as a specialised building block in solid-phase and solution-phase peptide synthesis. Its incorporation allows for the introduction of a non-natural amino acid with a cyano group, enabling diverse downstream modifications or specific interactions in the resulting peptide.
Organic Synthesis
This compound functions as a versatile intermediate in broader organic synthesis applications. The protected amino acid functionality and the presence of the nitrile group offer multiple reaction sites for constructing complex organic molecules and chemical probes.
Chemical Biology Research
Researchers in chemical biology can employ Fmoc-D-Phe(4-CN)-OH to synthesise peptides or peptidomimetics with unique properties. The cyano substituent can influence conformational preferences or serve as a handle for bioconjugation or further functionalisation.
| Molecular weight | 412.44 |
|---|---|
| Empirical formula | C25H20N2O4 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-Phe(4-CN)-OH used for?
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Fmoc-D-Phe(4-CN)-OH is primarily used as a specialised building block in peptide synthesis and general organic synthesis, particularly in chemical biology research, to introduce a cyano-substituted D-phenylalanine residue.
What are the CAS number and formula for Fmoc-D-Phe(4-CN)-OH?
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The CAS number for Fmoc-D-Phe(4-CN)-OH is 205526-34-7, and its molecular formula is C25H20N2O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and development purposes. The specific purity and grade are available upon request and are not guaranteed to be USP, BP, or EP compliant.
How should Fmoc-D-Phe(4-CN)-OH be handled?
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Refer to the Safety Data Sheet (SDS) for detailed handling, storage, and safety information. Appropriate personal protective equipment (PPE) should be worn, and the compound should be handled in a well-ventilated area.
Can I get a quote or sample for Fmoc-D-Phe(4-CN)-OH?
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Yes, to request a quote or a sample, please contact our sales team through the website or by phone. Please provide the product name and CAS number.
Is Fmoc-D-Phe(4-CN)-OH exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Fmoc-D-Phe(4-CN)-OH.
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