Fmoc-D-Phe(4-I)-OH

CAS 205526-29-0C24H20INO4Chemical Synthesis

Fmoc-D-Phe(4-I)-OH (CAS: 205526-29-0) is a protected unnatural amino acid derivative with the molecular formula C24H20INO4 and a molecular weight of 513.32 g/mol. This compound is primarily utilised in peptide synthesis and chemical biology research. Its structure incorporates a 4-iodo-D-phenylalanine residue protected with an Fmoc group, making it a valuable building block for creating complex peptides and peptidomimetics with modified properties.

IUPAC: Fmoc-4-iodo-D-phenylalanine

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Fmoc-D-Phe(4-I)-OH (C24H20INO4) — chemical structure, CAS 205526-29-0; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical BiologyChemical SynthesisPeptide ChemistryPhenylalanine Derivatives

01 /Applications

Peptide Synthesis

Fmoc-D-Phe(4-I)-OH serves as a key building block in solid-phase peptide synthesis (SPPS) using Fmoc chemistry. The iodine substituent allows for further functionalization or acts as a heavy atom for structural studies.

Chemical Biology

This unnatural amino acid derivative is employed in chemical biology to introduce specific structural modifications into peptides. These modifications can influence biological activity, stability, or facilitate bioconjugation.

Drug Discovery

Incorporating Fmoc-D-Phe(4-I)-OH into peptide-based drug candidates can alter their pharmacokinetic profiles or target interactions. The iodinated phenylalanine moiety offers a handle for radiolabelling or developing novel therapeutic agents.

Organic Synthesis

As a specialised reagent, it is used in advanced organic synthesis for constructing complex molecules containing non-proteinogenic amino acids, contributing to the development of novel chemical entities.

02 /Properties

Molecular weight	513.32
Empirical formula	C24H20INO4
Assay	≥96.0% (HPLC)
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

205526-29-0

MDL number

MFCD00672557

Beilstein registry

9159551

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-D-Phe(4-I)-OH used for?

Fmoc-D-Phe(4-I)-OH is used as a building block in peptide synthesis, particularly within Fmoc-based solid-phase peptide synthesis, and in chemical biology research for creating modified peptides and peptidomimetics.

What is the CAS number and molecular formula for Fmoc-D-Phe(4-I)-OH?

The CAS number for Fmoc-D-Phe(4-I)-OH is 205526-29-0, and its molecular formula is C24H20INO4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-D-Phe(4-I)-OH with an assay of ≥96.0% (HPLC). TSS does not represent this product as USP, BP, or EP grade.

How should Fmoc-D-Phe(4-I)-OH be handled and stored?

Handling requires appropriate personal protective equipment, including eyeshields, gloves, and a respirator filter (type N95 or P1). Store the compound at 2-8°C.

How is this chemical packed, shipped, and exported?

Tech Serve Solutions packs, ships, and exports fine chemicals globally, adhering to all relevant regulations for safe and compliant transport. Specific packaging details are available upon request.

How can I request a sample or a quote for Fmoc-D-Phe(4-I)-OH?

To request a sample or a quote, please contact our sales team through the website or by phone, providing the product name and CAS number (205526-29-0).