p-Toluenesulfonic anhydride
p-Toluenesulfonic anhydride (CAS: 4124-41-8), with the linear formula (CH₃C₆H₄SO₂)₂O and a molecular weight of 326.39 g/mol, is a key organic building block and sulfur compound. It serves as a reactive anhydride in organic synthesis. Primarily utilised as a reagent in various chemical transformations, it is essential for constructing complex organic molecules in research and industrial applications. TSS supplies this compound with an assay of 97%.

Reagent in Palladium-Catalyzed Reactions
p-Toluenesulfonic anhydride is employed as a reagent in palladium-catalyzed allylic alkenylation reactions. It facilitates the coupling of allylic alcohols with acrylates, enabling the synthesis of functionalised alkenes.
Organic Synthesis Intermediate
As a reactive anhydride, it functions as a versatile intermediate in the synthesis of various organic compounds. Its structure allows for facile derivatisation and incorporation into complex molecular frameworks.
Building Block for Complex Molecules
It serves as a valuable building block in multi-step syntheses, contributing to the construction of specialised chemical entities for research and development purposes.
| Molecular weight | 326.39 |
|---|---|
| Linear formula | (CH3C6H4SO2)2O |
| Assay | 97% |
| Application | p-Toluenesulfonic anhydride has been employed as reagent in palladium-catalyzed allylic alkenylation of allylic alcohols with n-butyl acrylate1. |
| Melting point | 121-127 °C(lit.) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2585 8/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is p-Toluenesulfonic anhydride used for?
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p-Toluenesulfonic anhydride (CAS: 4124-41-8) is used as a reagent in palladium-catalyzed allylic alkenylation reactions and as a versatile building block in organic synthesis for constructing complex molecules.
What are the CAS number and chemical formula for p-Toluenesulfonic anhydride?
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The CAS number for p-Toluenesulfonic anhydride is 4124-41-8. Its linear formula is (CH₃C₆H₄SO₂)₂O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies p-Toluenesulfonic anhydride with an assay of 97%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should p-Toluenesulfonic anhydride be handled safely?
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p-Toluenesulfonic anhydride is a corrosive substance that causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection, must be worn. Handle in a well-ventilated area and avoid contact with skin, eyes, and clothing.
Is p-Toluenesulfonic anhydride packed and shipped internationally?
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Yes, p-Toluenesulfonic anhydride is carefully packed according to transport regulations (UN 2585, Class 8, PG III) and is available for export globally by Tech Serve Solutions.
How can I request a sample or obtain a quote for p-Toluenesulfonic anhydride?
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To request a sample or obtain a quote for p-Toluenesulfonic anhydride, please contact our sales team through the TSS website or by phone, providing your specific requirements and shipping details.
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