p-Toluenesulfonyl fluoride
p-Toluenesulfonyl fluoride (CAS 455-16-3, CH3C6H4SO2F) is a white crystalline solid with a molecular weight of 174.19 g/mol. This organosulfur compound serves as a valuable building block in organic synthesis, particularly within fluorinated and sulfonyl halide chemistry. Its applications include use in biochemical research for studying enzymes and in the separation of biological membranes. Tech Serve Solutions supplies this chemical with a minimum assay of 98%.
Biochemical Research
p-Toluenesulfonyl fluoride has been utilised in studies involving enzymes, such as the DNS polymerase derived from spinach leaf extracts. It aids in the investigation of enzyme activity and function.
Membrane Separation Studies
This compound has been employed in research related to the isolation and separation of biological membranes, specifically from Pseudomonas aeruginosa, using density sucrose gradient centrifugation techniques.
Organic Synthesis Intermediate
As a fluorinated building block and sulfonyl halide, p-Toluenesulfonyl fluoride is a useful reagent in the synthesis of more complex organic molecules. Its reactivity makes it suitable for introducing the tosyl group in various chemical transformations.
| Molecular weight | 174.19 |
|---|---|
| Linear formula | CH3C6H4SO2F |
| Assay | 98% |
| Boiling point | 112 °C/16 mmHg(lit.) |
| Application | p-Toluenesulfonyl fluoride was used to study the DNS polymerase from spinach leaf extracts1. It was used in isolation and separation of Pseudomonas aeruginosa membranes by density sucrose gradient centrifugation2.polar organic solvents: soluble (lit.)(lit.) |
| Melting point | 41-42 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H314Causes severe skin burns and eye damage
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 106 °C / 222.8 °F |
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 20/21/22-34 |
| Safety statements (S) | 22-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is p-Toluenesulfonyl fluoride used for?
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p-Toluenesulfonyl fluoride is used as a building block in organic synthesis, in biochemical research for enzyme studies, and in the separation of biological membranes. It is particularly useful in fluorinated and sulfonyl halide chemistry.
What is the CAS number and chemical formula for p-Toluenesulfonyl fluoride?
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The CAS number is 455-16-3 and the chemical formula is CH3C6H4SO2F.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies p-Toluenesulfonyl fluoride with a minimum assay of 98%. This is a research grade chemical and is not represented as USP, BP, or EP grade.
How should p-Toluenesulfonyl fluoride be handled safely?
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p-Toluenesulfonyl fluoride is classified as Danger, with hazards including H302 (Harmful if swallowed), H312 (Harmful in contact with skin), H314 (Causes severe skin burns and eye damage), and H332 (Harmful if inhaled). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection (e.g., N100 or P3 filter), is essential. Handle in a well-ventilated area or fume hood.
How is p-Toluenesulfonyl fluoride shipped and exported?
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p-Toluenesulfonyl fluoride is shipped and exported under UN 3261, Hazard Class 8, Packing Group II, indicating it is a corrosive solid, acidic, organic, n.o.s. Tech Serve Solutions complies with all international shipping regulations.
How can I request a quote or sample of p-Toluenesulfonyl fluoride?
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To request a quote or a sample of p-Toluenesulfonyl fluoride, please contact our sales department via the website or direct telephone inquiry.
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