p-Toluenesulfonylmethyl isocyanide
p-Toluenesulfonylmethyl isocyanide (CAS: 36635-61-7), with the molecular formula CH3C6H4SO2CH2NC and a molecular weight of 195.24 g/mol, is a versatile organic compound. It serves as a valuable building block and reagent in complex chemical synthesis. Its properties make it particularly useful in the construction of heterocyclic compounds and other sophisticated organic structures.
- IUPAC
- (p-Tolylsulfonyl)methyl isocyanide,TosMIC,Tosylmethyl isocyanide
- Synonyms
- (p-Tolylsulfonyl)methyl isocyanideTosMICTosylmethyl isocyanide
Organic Synthesis Reagent
p-Toluenesulfonylmethyl isocyanide, often referred to as TosMIC, is widely employed as a synthon in organic chemistry. It facilitates diverse transformations, including cycloadditions and nucleophilic additions, contributing to the efficient construction of complex molecular architectures.
Heterocyclic Chemistry
This isocyanide is a key intermediate for the synthesis of various heterocyclic systems. It is instrumental in forming rings containing nitrogen and other heteroatoms, which are prevalent in pharmaceuticals and agrochemicals.
Building Block for Fine Chemicals
As a functionalised organic building block, TosMIC is utilised in the multi-step synthesis of fine chemicals. Its unique reactivity allows for the introduction of specific functional groups and structural motifs.
| Molecular weight | 195.24 |
|---|---|
| Linear formula | CH3C6H4SO2CH2NC |
| Assay | 98% |
| Solubility | water: slightly soluble |
| Storage temperature | 2-8°C |
| Melting point | 109-113 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25 |
| Safety statements (S) | 36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is p-Toluenesulfonylmethyl isocyanide used for?
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p-Toluenesulfonylmethyl isocyanide (TosMIC) is primarily used as a reagent in organic synthesis, particularly for the construction of heterocyclic compounds and as a versatile building block in the synthesis of complex organic molecules.
What is the CAS number and formula for p-Toluenesulfonylmethyl isocyanide?
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The CAS number for p-Toluenesulfonylmethyl isocyanide is 36635-61-7, and its linear formula is CH3C6H4SO2CH2NC.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies p-Toluenesulfonylmethyl isocyanide with an assay of 98%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should p-Toluenesulfonylmethyl isocyanide be handled safely?
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p-Toluenesulfonylmethyl isocyanide is classified as acutely toxic (oral, dermal, inhalation). Handling requires strict adherence to safety protocols, including the use of eyeshields, face shields, gloves, and appropriate respiratory protection (e.g., P2 respirator cartridges). Ensure good ventilation. Always consult the Safety Data Sheet (SDS) before use.
How is p-Toluenesulfonylmethyl isocyanide packaged and exported?
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p-Toluenesulfonylmethyl isocyanide is packaged according to industry standards to ensure safe transport and is exported globally by Tech Serve Solutions.
How can I request a sample or quote for p-Toluenesulfonylmethyl isocyanide?
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To request a sample or a quote for p-Toluenesulfonylmethyl isocyanide, please contact the Tech Serve Solutions sales team through our website or by calling us.
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