p-Toluenesulfonyl isocyanate
p-Toluenesulfonyl isocyanate (CAS: 4083-64-1, Formula: CH3C6H4SO2NCO, MW: 197.21) is a key organic building block and chemical synthesis reagent. It is primarily employed as a derivatisation agent in analytical chemistry and for the preparation of various organic compounds including oxazolidin-2-ones and N-tosylcarbonamides. Tech Serve Solutions offers this compound with a typical assay of 96%.
- IUPAC
- Tosyl isocyanate
Derivatisation Reagent in Pharmaceutical Analysis
p-Toluenesulfonyl isocyanate is utilised as a derivatisation reagent for the sensitive determination of specific compounds, such as 3-α-hydroxy tibolone in human plasma via LC-MS/MS. It also aids in the simultaneous quantitative analysis of diethylene glycol and propylene glycol in pharmaceutical products using HPLC.
Synthesis of Organic Intermediates
This isocyanate serves as a valuable reagent in organic synthesis for the preparation of diverse chemical structures. It is instrumental in the synthesis of acetylated syn-1,2-diols, oxazolidin-2-ones, and 2,3-diamino acids.
Preparation of N-Tosylcarbonamides
p-Toluenesulfonyl isocyanate is a specific reagent used in the laboratory for the efficient preparation of N-tosylcarbonamides, contributing to the synthesis of complex nitrogen-containing organic molecules.
| Molecular weight | 197.21 |
|---|---|
| Linear formula | CH3C6H4SO2NCO |
| Assay | 96% |
| Boiling point | 144 °C/10 mmHg(lit.)275-278 °C(lit.) |
| Density | 1.291 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.534(lit.) |
| Vapour pressure | 1 mmHg (100 °C) |
| Application | p-Toluenesulfonyl isocyanate has been used as :• derivatization reagent in determination of 3-α-hydroxy tibolone in human plasma by LC-MS/MS1 • derivatization reagent in simultaneous quantitative analysis of diethylene glycol and propylene glycol in pharmaceutical products by HPLC2 • as reagent in the preparation of acetylated syn-1,2-diols3, oxazolidin-2-ones4, 2,3-diamino acids5 and N-tosylcarbonamides6 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
- P342
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 145 °C / 293 °F |
| Transport (UN / ADR) | UN 2206 6.1/PG 3 |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 14-36/37/38-42 |
| Safety statements (S) | 26-28-30 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is p-Toluenesulfonyl isocyanate used for?
+
p-Toluenesulfonyl isocyanate is primarily used as a derivatisation reagent in analytical chemistry, particularly for LC-MS/MS and HPLC methods, and as a reagent in organic synthesis for preparing compounds like oxazolidin-2-ones and N-tosylcarbonamides.
What are the CAS number and chemical formula for p-Toluenesulfonyl isocyanate?
+
The CAS number is 4083-64-1, and the chemical formula is CH3C6H4SO2NCO.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies p-Toluenesulfonyl isocyanate with a minimum assay of 96%. This is a technical or research grade material, and TSS does not represent it as USP, BP, or EP grade.
What are the primary safety concerns when handling p-Toluenesulfonyl isocyanate?
+
p-Toluenesulfonyl isocyanate is a hazardous substance. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Crucially, it can cause allergy or asthma symptoms or breathing difficulties if inhaled (H334) and reacts violently with water. Appropriate personal protective equipment, including gloves, eyeshields, and respiratory protection, must be used. Handle only in a well-ventilated area.
How is p-Toluenesulfonyl isocyanate packed, shipped, and exported?
+
p-Toluenesulfonyl isocyanate is carefully packed in compliance with international shipping regulations for hazardous materials (UN 2206). Tech Serve Solutions is experienced in global export and can provide quotations for your specific destination.
How can I request a sample or a quote for p-Toluenesulfonyl isocyanate?
+
To request a sample or obtain a quote, please use the contact form on our website or email our sales department directly, specifying the product name, CAS number, and quantity required.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis