p-Toluenesulfonyl chloride
p-Toluenesulfonyl chloride (CAS: 98-59-9; Formula: CH3C6H4SO2Cl) is a significant organosulfur compound with a molar mass of 190.65 g/mol. This reactive compound serves as a crucial intermediate in organic synthesis. It is widely employed as a derivatization reagent in analytical chemistry, particularly for enhancing the detectability of various compounds in techniques like HPLC. Its utility extends to the protection of amine and alcohol functional groups during complex synthetic pathways.
- IUPAC
- Tosyl chloride
- Synonyms
- Tosyl chloridePTSClp-Tosic acid chloride4-Methylbenzenesulfonyl chloride
Organic Synthesis Intermediate
p-Toluenesulfonyl chloride is a versatile building block in the synthesis of more complex organic molecules. It is frequently used for the tosylation of alcohols and amines, a common strategy in protecting functional groups or preparing sulfonates for further reactions.
Derivatization Reagent
In analytical chemistry, this compound is employed to derivatise analytes, thereby improving their chromatographic properties or detectability, especially in HPLC. It reacts with primary and secondary amines, as well as alcohols, to form stable sulfonamides or sulfonates.
Reagent for Functional Group Protection
The tosyl group derived from p-toluenesulfonyl chloride is a widely used protecting group for alcohols and amines in multi-step organic syntheses. Its stability under various reaction conditions and straightforward cleavage make it an efficient choice.
| Molecular weight | 190.65 |
|---|---|
| Linear formula | CH3C6H4SO2Cl |
| Assay | ≥97.0% (AT) |
| Boiling point | 134 °C/10 mmHg(lit.) |
| Vapour pressure | 1 mmHg (88 °C) |
| Melting point | 65-69 °C(lit.)65-69 °C |
Hazard statements
- H315Causes skin irritation
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 128 °C / 262.4 °F |
| Transport (UN / ADR) | UN 3261 8 / PGIII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is p-Toluenesulfonyl chloride used for?
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p-Toluenesulfonyl chloride is primarily used as an intermediate in organic synthesis, a reagent for derivatising alcohols and amines, and for protecting functional groups during complex chemical reactions. It is also employed in analytical chemistry, particularly for enhancing detection in HPLC.
What is the CAS number and chemical formula for p-Toluenesulfonyl chloride?
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The CAS number for p-Toluenesulfonyl chloride is 98-59-9, and its chemical formula is CH3C6H4SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies p-Toluenesulfonyl chloride with an assay of ≥97.0% (AT). We do not represent this product as USP, BP, or EP grade unless explicitly stated in the product specifications.
What are the main safety hazards associated with p-Toluenesulfonyl chloride?
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p-Toluenesulfonyl chloride is classified as dangerous. It causes skin irritation (H315) and serious eye damage (H318). Appropriate personal protective equipment, including eye shields, face shields, and gloves, must be worn when handling this chemical. Refer to the Safety Data Sheet for detailed handling procedures.
How is p-Toluenesulfonyl chloride packed and shipped?
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p-Toluenesulfonyl chloride is packed and shipped according to relevant transport regulations, including UN 3261 for corrosive solid organic, acidic, n.o.s. We export globally, adhering to all international shipping standards.
How can I request a sample or quote for p-Toluenesulfonyl chloride?
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To request a sample or a quotation for p-Toluenesulfonyl chloride, please use the contact form on our website or reach out to our sales department directly. Provide the product name and CAS number for faster service.
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