Tyrphostin AG 1478

CAS 175178-82-2C16H14ClN3O2Biochemicals & Reagents

Tyrphostin AG 1478 (CAS: 175178-82-2), with the molecular formula C16H14ClN3O2 and a molecular weight of 315.75 g/mol, is a selective inhibitor of the Epidermal Growth Factor Receptor (EGFR) tyrosine kinase. This compound is invaluable in biochemical research for studying cell signalling pathways, particularly those involving EGFR. It is supplied by Tech Serve Solutions for laboratory and research applications, adhering to stringent quality standards.

IUPAC: N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine

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Tyrphostin AG 1478 (C16H14ClN3O2) — chemical structure, CAS 175178-82-2; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand SubstratesKinase/Phosphatase BiologyMolecular Biology

01 /Applications

Epidermal Growth Factor Receptor (EGFR) Inhibition

Tyrphostin AG 1478 is employed as a selective inhibitor of EGFR tyrosine kinase activity. It has been used in cell culture studies to investigate the role of EGFR signaling in various biological processes.

Cell Signaling Pathway Research

This compound serves as a vital tool in the study of cell signaling cascades regulated by growth factors. Its ability to block EGFR phosphorylation allows researchers to dissect downstream signaling events.

Biochemical Assays

Used in vitro and in cell-based assays to understand the function and inhibition of EGFR, contributing to the development of targeted therapies and understanding disease mechanisms.

02 /Properties

Molecular weight	315.75
Empirical formula	C16H14ClN3O2
Assay	≥98%
Solubility	0.1 M HCl: soluble DMSO:methanol (1:1): soluble10 mg/mL, clear, colorlessethanol: soluble10 mg/mLmethylene chloride: soluble10 mg/mL0.1 M NaOH: insoluble2-hydroxypropyl-β-cyclodextrin: insolubleH2O: insoluble
Storage temperature	2-8°C
Application	Tyrphostin AG 1478 has been used as an EGF receptor (EGFR) inhibitor in SW1353 cultures2. AG 1478 is also known to inhibit exogenous TGFα-mediated c-Met phosphorylation in A431 cells3.

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

175178-82-2

MDL number

MFCD00270914

PubChem substance

24278735

05 /Additional specifications

Gene Information	human ... EGFR(1956)mouse ... Egfr(13649)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Tyrphostin AG 1478 used for?

Tyrphostin AG 1478 is used as a selective inhibitor of the Epidermal Growth Factor Receptor (EGFR) tyrosine kinase in research settings to study cell signalling pathways.

What is the CAS number and formula for Tyrphostin AG 1478?

The CAS number for Tyrphostin AG 1478 is 175178-82-2, and its molecular formula is C16H14ClN3O2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Tyrphostin AG 1478 with an assay of ≥98%. This product is intended for research and laboratory use and is not supplied as USP, BP, EP, or pharmacopoeia grade.

How should Tyrphostin AG 1478 be handled and stored?

Handle Tyrphostin AG 1478 with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 respirator filter. Store at 2-8°C.

Is Tyrphostin AG 1478 a controlled substance?

Based on the provided data, Tyrphostin AG 1478 is not listed as a controlled substance. However, users should always verify local regulations.

How is Tyrphostin AG 1478 shipped and exported?

Tech Serve Solutions is a global supplier and exporter of fine chemicals and reagents. Tyrphostin AG 1478 is carefully packaged and shipped according to international shipping regulations for research chemicals.

How can I request a quote or sample for Tyrphostin AG 1478?

To request a quote or a sample of Tyrphostin AG 1478, please contact our sales team through the website or by calling us. Details for sample requests and quotes are available in the 'Contact Us' section.