Tyrphostin RG 13022

CAS 136831-48-6C16H14N2O2Biochemicals & Reagents

Tyrphostin RG 13022 (CAS: 136831-48-6; Formula: C16H14N2O2; MW: 266.29) is a potent inhibitor of the Epidermal Growth Factor Receptor (EGFR) tyrosine kinase. This biochemical reagent is vital for research in cell signalling, neuroscience, and cancer biology. Its specific action on EGFR makes it a valuable tool for investigating cellular proliferation and differentiation pathways. Available from Tech Serve Solutions, it supports advanced molecular and cellular research.

IUPAC: 2-(3,4′-Dimethoxyphenyl)-1-(3″-pyridinyl)acrylonitrile

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Tyrphostin RG 13022 (C16H14N2O2) — chemical structure, CAS 136831-48-6; Life Science, fine chemical supplied by Tech Serve Solutions

Biochemicals and ReagentsCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand SubstratesKinase/Phosphatase BiologyP to QProtein Kinase Inhibitors

01 /Applications

EGFR Tyrosine Kinase Inhibition

Tyrphostin RG 13022 serves as a key research tool for studying the role of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase in cellular processes. It is used to investigate signal transduction pathways involved in cell growth, differentiation, and survival.

Cellular Signalling Research

This compound is instrumental in cell biology research, particularly in understanding signal transduction mechanisms. It helps elucidate the complex interplay of pathways regulated by receptor tyrosine kinases.

Neuroscience Studies

In neuroscience, Tyrphostin RG 13022 aids in exploring the functions of EGFR signalling in neural development and function. Its inhibitory action provides insights into neurological processes.

02 /Properties

Molecular weight	266.29
Empirical formula	C16H14N2O2
Assay	≥98%
Solubility	DMSO or ethanol: soluble
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

136831-48-6

05 /Additional specifications

Potency	IC50 (3 micromolar for inhibition of EGF-receptor.)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Tyrphostin RG 13022 used for?

Tyrphostin RG 13022 is used as a research tool to inhibit Epidermal Growth Factor Receptor (EGFR) tyrosine kinase, aiding studies in cell signalling, neuroscience, and cell biology, particularly concerning cellular proliferation and differentiation.

What is the CAS number and molecular formula for Tyrphostin RG 13022?

The CAS number for Tyrphostin RG 13022 is 136831-48-6, and its molecular formula is C16H14N2O2.

What grade and purity does Tech Serve Solutions supply for Tyrphostin RG 13022?

Tech Serve Solutions supplies Tyrphostin RG 13022 with an assay of ≥98%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or pharmaceutical grade.

What are the safety and handling precautions for Tyrphostin RG 13022?

When handling Tyrphostin RG 13022, appropriate personal protective equipment must be worn, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. The compound carries a WGK Germany rating of 3, indicating a high hazard to water.

How is Tyrphostin RG 13022 shipped and exported by Tech Serve Solutions?

Tyrphostin RG 13022 is stored at 2-8°C. Tech Serve Solutions, a specialist global supplier and exporter, ensures appropriate packaging and handling for international shipment.