Tyrphostin AG 490
Tyrphostin AG 490 (CAS: 133550-30-8, C17H14N2O3) is a yellow crystalline solid with a molecular weight of 294.30 g/mol. This compound acts as an inhibitor for Janus kinase (JAK) family members, including JAK2. It is utilised in biochemical research to study cell signalling pathways, particularly those involving cytokine signalling and the inhibition of protein tyrosine kinases.
- IUPAC
- 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide,2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
JAK2 Inhibition
Tyrphostin AG 490 serves as a selective inhibitor for JAK2. It has been employed in studies involving human umbilical vein endothelial cells to investigate the role of JAK2 in cellular processes.
Cytokine Signalling Blockade
This compound is used to block Interleukin-6 (IL-6) cytokine signalling. Research applications include studying the impact of IL-6 inhibition on glial cell reactivity.
Protein Tyrosine Kinase Inhibition
As a tyrphostin derivative, AG 490 functions as an inhibitor of protein tyrosine kinases. It is a valuable tool for researchers investigating kinase-dependent cellular pathways.
| Molecular weight | 294.30 |
|---|---|
| Empirical formula | C17H14N2O3 |
| Form | solid |
| Colour | yellow |
| Solubility | DMSO: soluble10 mg/ml, clear, yellowethanol: soluble5 mg/mLH2O: insoluble |
| Storage temperature | −20°C |
| Application | Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity5. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells6. |
Hazard statements
- H301Toxic if swallowed
- H400Very toxic to aquatic life
Precautionary statements
- P273Avoid release to the environment
- P301IF SWALLOWED
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | T,N |
| Risk statements (R) | 25-50 |
| Safety statements (S) | 45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... EGFR(1956), ERBB2(2064), IL2(3558), JAK2(3717) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tyrphostin AG 490 used for?
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Tyrphostin AG 490 is primarily used in research as an inhibitor of Janus Kinase 2 (JAK2) and other protein tyrosine kinases. It is employed to study cytokine signalling pathways, such as those involving IL-6, and their effects on cell reactivity and signalling cascades.
What are the CAS number and chemical formula for Tyrphostin AG 490?
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The CAS number for Tyrphostin AG 490 is 133550-30-8, and its empirical formula is C17H14N2O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tyrphostin AG 490 as a research-grade chemical. The purity is not specified as USP, BP, or EP. For specific batch purity, please consult the Certificate of Analysis.
How should Tyrphostin AG 490 be handled and stored?
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Tyrphostin AG 490 is classified as toxic if swallowed and very toxic to aquatic life with long lasting effects. Handle with appropriate personal protective equipment, avoid release to the environment, and store at -20°C.
Is Tyrphostin AG 490 a controlled substance?
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The provided data does not indicate that Tyrphostin AG 490 is a controlled substance.
How can I request a quote or sample for Tyrphostin AG 490?
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To request a quote or sample for Tyrphostin AG 490, please contact our sales team through the website or by phone. Specify the quantity required and your shipping details.
How is Tyrphostin AG 490 packed and shipped?
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Tyrphostin AG 490 is typically packed in secure containers suitable for chemical transport and shipped according to international regulations for hazardous materials. We export globally.
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