Tyrphostin RG 14620
Tyrphostin RG 14620 (CAS: 136831-49-7) is a chemical compound with the empirical formula C14H8Cl2N2 and a molecular weight of 275.13. This dichlorophenyl acrylonitrile derivative functions as a potent inhibitor of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase. It is primarily utilised in biochemical research and cell biology studies, particularly for investigating cell signalling pathways and the role of receptor tyrosine kinases in cellular processes.
- IUPAC
- 2-(3′,5′-Dichlorophenyl)-1-(3″-pyridinyl)acrylonitrile
EGFR Tyrosine Kinase Inhibition
Tyrphostin RG 14620 serves as a research tool for inhibiting Epidermal Growth Factor Receptor (EGFR) tyrosine kinase activity. Its potency, with an IC50 of 3 micromolar for EGFR inhibition, makes it valuable for studying EGFR-mediated cellular functions.
Cell Signalling Research
This compound is employed in cell biology to investigate downstream signalling cascades regulated by EGFR. Researchers use it to understand the intricate pathways involved in cell growth, proliferation, and differentiation.
Receptor Tyrosine Kinase Studies
As an inhibitor of receptor tyrosine kinases, Tyrphostin RG 14620 aids in the study of the broader family of RTKs and their roles in both normal physiological processes and disease states.
| Molecular weight | 275.13 |
|---|---|
| Empirical formula | C14H8Cl2N2 |
| Assay | ≥98% |
| Solubility | DMSO: soluble |
| Storage temperature | −20°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Potency | IC50 (3 micromolar for inhibition of EGF-receptor.) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tyrphostin RG 14620 used for?
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Tyrphostin RG 14620 is primarily used as a research chemical for inhibiting Epidermal Growth Factor Receptor (EGFR) tyrosine kinase and investigating cell signalling pathways.
What are the CAS number and formula for Tyrphostin RG 14620?
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The CAS number for Tyrphostin RG 14620 is 136831-49-7, and its empirical formula is C14H8Cl2N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tyrphostin RG 14620 with an assay of ≥98%. This is a research-grade chemical and not represented as USP, BP, EP, or other pharmacopoeia grades.
What are the safety and handling requirements for Tyrphostin RG 14620?
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Handling Tyrphostin RG 14620 requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified with a WGK Germany of 3, indicating it is hazardous to water.
How is Tyrphostin RG 14620 stored and shipped?
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Tyrphostin RG 14620 should be stored at -20°C. Tech Serve Solutions is a global supplier and exporter, capable of shipping this chemical worldwide.
How can I request a quote or sample for Tyrphostin RG 14620?
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To request a quote or a sample of Tyrphostin RG 14620, please contact our sales team through the TSS website or by phone.
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