Tyrphostin AG 1024

CAS 65678-07-1C14H13BrN2OBiochemicals & Reagents

Tyrphostin AG 1024 (CAS 65678-07-1) is a yellow solid with a molecular weight of 305.17 g/mol and an assay of ≥98%. This potent inhibitor is primarily used in biochemical research to study cell signalling pathways. It selectively targets and blocks specific receptor tyrosine kinases, including the Insulin-Like Growth Factor Receptor (IGF-IR), making it a valuable tool for investigating IGF-I signalling and its downstream effects in various cell types.

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Tyrphostin AG 1024 (C14H13BrN2O) — chemical structure, CAS 65678-07-1; Life Science, fine chemical supplied by Tech Serve Solutions

Biochemicals and ReagentsCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand SubstratesKinase/Phosphatase BiologyP to QProtein Kinase Inhibitors

01 /Applications

IGF-IR Signalling Studies

Tyrphostin AG 1024 has been employed to effectively block IGF-IR in experimental models, aiding the analysis of IGF-I signalling pathways within siSphK1 cells.

Collagen Synthesis Research

This compound has been utilised in studies investigating the effects of IGF-I on collagen synthesis in human dermal fibroblasts, offering insights into extracellular matrix regulation.

Enzyme Inhibition Research

As a tyrosine kinase inhibitor, Tyrphostin AG 1024 is a key reagent for researchers studying the function and regulation of receptor tyrosine kinases and their role in cellular processes.

02 /Properties

Molecular weight	305.17
Empirical formula	C14H13BrN2O
Assay	≥98%
Form	solid
Colour	yellow
Solubility	DMSO: solubleethanol: insoluble
Storage temperature	−20°C
Application	Tyrphostin AG 1024 has been used to block IGF-IR during the analysis of IGF-I signaling in siSphK1 cells3. AG-1024 has also been used to study IGF-I-induced collagen synthesis in human dermal fibroblasts4.

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

65678-07-1

05 /Additional specifications

Potency	0.4 μM IC50

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Tyrphostin AG 1024 used for?

Tyrphostin AG 1024 is used in research to block Insulin-Like Growth Factor Receptor (IGF-IR) and other tyrosine kinases, aiding studies in cell signalling, IGF-I pathways, and collagen synthesis.

What are the CAS number and formula for Tyrphostin AG 1024?

The CAS number for Tyrphostin AG 1024 is 65678-07-1, and its empirical formula is C14H13BrN2O.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Tyrphostin AG 1024 with an assay of ≥98%. This product is intended for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.

What are the safety and handling requirements for Tyrphostin AG 1024?

Handling Tyrphostin AG 1024 requires personal protective equipment including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It has a WGK Germany rating of 3, indicating it is hazardous to water.

How is Tyrphostin AG 1024 packed, shipped, and exported?

Tyrphostin AG 1024 is supplied as a yellow solid, typically stored at -20°C. Tech Serve Solutions specialises in global export of fine chemicals and laboratory reagents.