Tyrphostin 63
Tyrphostin 63 (CAS: 5553-97-9), with the molecular formula C10H8N2O and a molecular weight of 172.18 g/mol, is a potent inhibitor primarily studied for its effects on Epidermal Growth Factor Receptor (EGFR) tyrosine kinases. This biochemical reagent is valuable in cell biology research, particularly for investigating cell signaling pathways, neuroscience, and kinase/phosphatase biology. It serves as a critical tool for understanding the role of RTKs in cellular processes.
- IUPAC
- 4-Hydroxybenzyl malononitrile
EGFR Tyrosine Kinase Inhibition
Tyrphostin 63 acts as an inhibitor of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase activity. This property makes it a key research tool for studying signalling pathways regulated by EGFR in various cellular contexts.
Cell Signaling Research
This compound is instrumental in cell biology and cell signaling research, enabling scientists to probe the mechanisms of tyrosine kinase-dependent cellular responses. Its application extends to neuroscience studies involving receptor tyrosine kinases.
Biochemical and Reagent Use
As a high-purity biochemical reagent, Tyrphostin 63 is supplied for laboratory use. It aids in the investigation of enzyme inhibition, specifically targeting protein tyrosine kinases involved in cell growth and differentiation.
| Molecular weight | 172.18 |
|---|---|
| Empirical formula | C10H8N2O |
| Assay | ≥98% |
| Solubility | DMSO: soluble |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Potency | 6500 μM IC50 (negative control) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tyrphostin 63 used for?
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Tyrphostin 63 is used as a research tool in cell biology and cell signaling, particularly for its inhibitory effects on Epidermal Growth Factor Receptor (EGFR) tyrosine kinases. It is valuable for studying kinase/phosphatase biology and receptor tyrosine kinase pathways.
What are the CAS number and formula for Tyrphostin 63?
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The CAS number for Tyrphostin 63 is 5553-97-9, and its molecular formula is C10H8N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tyrphostin 63 with an assay of ≥98%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should Tyrphostin 63 be handled?
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Handling Tyrphostin 63 requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It is classified under WGK Germany 3, indicating it is hazardous to water.
How is Tyrphostin 63 shipped and exported?
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Tyrphostin 63 is stored at 2-8°C. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, capable of shipping and exporting this product internationally.
How can I request a quote or sample for Tyrphostin 63?
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To request a quote or a sample of Tyrphostin 63, please contact our sales department through the TSS website or your designated representative.
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