Tyrphostin 23
Tyrphostin 23 (CAS: 118409-57-7), with the chemical formula C10H6N2O2 and a molecular weight of 186.17 g/mol, is a potent tyrosine kinase inhibitor. It plays a crucial role in biochemical research, particularly in cell signalling studies. This compound is recognised for its ability to inhibit epidermal growth factor receptor (EGFR) and other tyrosine kinases, making it valuable for investigating cellular pathways and disease mechanisms.
- IUPAC
- (3,4-Dihydroxybenzylidene)malononitrile,RG-50810
Tyrosine Kinase Inhibition Studies
Tyrphostin 23 is employed as a tyrosine kinase inhibitor in research settings. It has been utilised to study rat ghrelin-induced MAPK stimulation in GH3 cells, providing insights into cellular signalling pathways.
Chemotaxis Research
This compound has also been investigated for its effects on neutrophil chemotaxis. Specifically, it has been used to analyse the impact of Tyrphostin 23 on secretoneurin (SN)-induced neutrophil migration.
Cell Biology and Signalling Research
As a bioactive small molecule and enzyme inhibitor, Tyrphostin 23 is a valuable tool for cell biology and cell signalling research. It aids in understanding receptor tyrosine kinase biology and kinase/phosphatase pathways.
| Molecular weight | 186.17 |
|---|---|
| Empirical formula | C10H6N2O2 |
| Assay | ≥98% |
| Solubility | DMSO: soluble50 mg/mL, clear, yellow to brownish-yellow |
| Storage temperature | 2-8°C |
| Application | Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells1. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils2. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... CDK2(1017) |
|---|---|
| Potency | 35 μM IC50 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tyrphostin 23 used for?
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Tyrphostin 23 is a tyrosine kinase inhibitor used in research to study cellular signalling pathways, such as MAPK stimulation, and to investigate its effects on cell migration, like neutrophil chemotaxis.
What are the CAS number and formula for Tyrphostin 23?
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The CAS number for Tyrphostin 23 is 118409-57-7, and its chemical formula is C10H6N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tyrphostin 23 with a purity of ≥98% (Assay). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling recommendations for Tyrphostin 23?
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For safe handling of Tyrphostin 23, it is recommended to use appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is advised. The compound has a WGK Germany rating of 3.
How is Tyrphostin 23 stored and shipped?
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Tyrphostin 23 should be stored at 2-8°C. Tech Serve Solutions exports chemicals globally, adhering to all necessary shipping regulations.
How can I request a sample or quote for Tyrphostin 23?
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To request a sample or a quote for Tyrphostin 23, please contact our sales team through the website or by calling us directly. We are happy to assist with your research needs.
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