Tyrphostin 1
Tyrphostin 1 (CAS: 2826-26-8) is a chemical compound with the molecular formula C12H10N2O. This compound, also known by its IUPAC name (4-Methoxybenzylidene)malononitrile, has a molecular weight of 184.19 g/mol. It is primarily utilised in research settings, particularly in cell biology and signalling studies, for its role as an enzyme inhibitor.
- IUPAC
- (4-Methoxybenzylidene)malononitrile
Investigating Transgene Expression
Tyrphostin 1 has been employed in studies to observe its effects on increasing transgene expression within cell lines, specifically HeLa and NIH3T3 cells.
Enzyme Inhibition Research
As a tyrosine kinase inhibitor, Tyrphostin 1 is valuable for research into kinase/phosphatase biology and epidermal growth factor receptor (EGFR) signalling pathways.
Cellular Signalling Studies
This compound serves as a tool in understanding complex cellular signalling mechanisms, particularly those involving receptor tyrosine kinases.
| Molecular weight | 184.19 |
|---|---|
| Linear formula | CH3OC6H4CH=C(CN)2 |
| Assay | ≥98% |
| Solubility | chloroform: soluble50 mg/mL, clear, light yellowDMSO: soluble |
| Storage temperature | 2-8°C |
| Application | Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells1. |
| Melting point | 113-116 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... EGFR(1956) |
|---|---|
| Potency | >1250 μM IC50 (negative control) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tyrphostin 1 used for?
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Tyrphostin 1 is used in research, particularly in cell biology and signalling studies, and has been employed to investigate its effect on increasing transgene expression in cells.
What are the CAS number and molecular formula for Tyrphostin 1?
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The CAS number for Tyrphostin 1 is 2826-26-8 and its linear formula is CH₃OC₆H₄CH=C(CN)₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tyrphostin 1 with an assay of ≥98%. TSS does not represent this product as USP, BP, EP, or for pharmaceutical, nutraceutical, or food use.
What are the safety and handling requirements for Tyrphostin 1?
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Tyrphostin 1 requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter. It is classified with WGK Germany 3.
How is Tyrphostin 1 typically stored and shipped?
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Tyrphostin 1 should be stored at 2-8°C. Tech Serve Solutions safely packs, ships, and exports fine chemicals globally.
How can I request a quote or sample of Tyrphostin 1?
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Please contact our sales team to request a quote or a sample of Tyrphostin 1.
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