Tyrphostin 47
Tyrphostin 47 (CAS: 118409-60-2), with the molecular formula C10H8N2O2S and a molecular weight of 220.25 g/mol, is a bioactive small molecule and enzyme inhibitor. It is primarily utilised in biochemical research for its role in cell signaling studies, specifically as an inhibitor of protein tyrosine kinases like EGFR. Tyrphostin 47 has also been employed in screening assays to identify inhibitors of human tissue transglutaminase (TGM2) and in investigating its effects on ion channels in cellular models.
- IUPAC
- α-Cyano-3,4-dihydroxythiocinnamamide,3,4-Dihydroxy-α-cyanothiocinnamamide,RG 50864
- Synonyms
- α-Cyano-3,4-dihydroxythiocinnamamide3,4-Dihydroxy-α-cyanothiocinnamamideRG 50864
Biochemical Research and Screening
Tyrphostin 47 is utilized in biochemical assays, including LOPAC screening, to identify potential inhibitors of enzymes such as human tissue transglutaminase (TGM2).
Cell Signaling Studies
This compound serves as a tool in cell biology research to investigate signaling pathways, particularly those involving receptor tyrosine kinases like EGFR, and their role in cellular processes.
Ion Channel Research
Tyrphostin 47 has been used to study its effects on cellular electrophysiology, such as its impact on hyperpolarization-activated cation currents in specific cell types.
| Molecular weight | 220.25 |
|---|---|
| Empirical formula | C10H8N2O2S |
| Assay | ≥98% |
| Solubility | DMSO: soluble50 mg/mL, clear, orangeethanol: soluble |
| Storage temperature | 2-8°C |
| Application | Tyrphostin 47 has been used in LOPAC screening assays to identify human tissue transglutaminase (TGM2) inhibitors1. Tyrphostin 47 has also been used to study its effects on hyperpolarization-activated cation current in porcine pacemaker cells2. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... CDK2(1017), EGFR(1956) |
|---|---|
| Potency | 2.4 μM IC50 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tyrphostin 47 used for?
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Tyrphostin 47 is used in biochemical research as an enzyme inhibitor, notably for studies involving protein tyrosine kinases like EGFR, human tissue transglutaminase (TGM2), and in investigations of ion channel activity.
What is the CAS number and molecular formula for Tyrphostin 47?
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The CAS number for Tyrphostin 47 is 118409-60-2, and its molecular formula is C10H8N2O2S.
What grade and purity does Tech Serve Solutions supply for Tyrphostin 47?
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Tech Serve Solutions supplies Tyrphostin 47 with a purity of ≥98% (Assay). TSS does not represent this product as USP, BP, EP, or pharmaceutical grade.
What are the safety considerations when handling Tyrphostin 47?
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Tyrphostin 47 is classified with a Warning signal word and has hazard statements H315, H319, and H335, indicating it may cause skin irritation, eye irritation, and respiratory irritation. Handle with appropriate personal protective equipment in a well-ventilated area.
How is Tyrphostin 47 typically packaged and shipped?
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Tyrphostin 47 is typically stored at 2-8°C. TSS can pack and export this chemical globally, adhering to all relevant shipping regulations.
How can I request a sample or quote for Tyrphostin 47?
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To request a sample or obtain a quote for Tyrphostin 47, please contact our sales team through the website or by phone, providing the product name and CAS number.
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