Tyrphostin A9
Tyrphostin A9 (CAS: 10537-47-0), a yellow solid with the molecular formula C18H22N2O and a molecular weight of 282.38 g/mol, is a potent inhibitor of tyrosine kinase functions. It is recognised for its role in disrupting membrane potential in mammalian cells and its application in biological research, specifically within cell biology and neuroscience studies. This compound is supplied for laboratory and research purposes.
- IUPAC
- Malonoben,[[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile
Inhibition of Tyrosine Kinase Functions
Tyrphostin A9 serves as a valuable tool for inhibiting tyrosine kinase activities, demonstrated in experimental settings such as C2C12 cell cultures. This application aids researchers in investigating cellular signalling pathways regulated by these enzymes.
Disruption of Membrane Potential
This compound has been utilised to disrupt the membrane potential in various mammalian cell types. This property makes it useful for studies focused on cellular electrophysiology and membrane dynamics.
Research in Cell Biology
As a bioactive small molecule, Tyrphostin A9 is employed in cell biology research to understand cellular processes and responses, particularly those involving kinase signalling.
| Molecular weight | 282.38 |
|---|---|
| Empirical formula | C18H22N2O |
| Form | solid |
| Colour | yellow |
| Solubility | ethanol: soluble20 mg/mLDMSO: H2O: insoluble |
| Application | Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells1. It has also been used to disrupt membrane potential in mammalian cells2. |
Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25 |
| Safety statements (S) | 36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tyrphostin A9 used for?
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Tyrphostin A9 is used for inhibiting tyrosine kinase functions in experimental models and for disrupting membrane potential in mammalian cells. It is a tool for research in cell biology and neuroscience.
What are the CAS number and formula for Tyrphostin A9?
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Tyrphostin A9 has the CAS number 10537-47-0 and its molecular formula is C18H22N2O.
What grade and purity does Tech Serve Solutions supply for Tyrphostin A9?
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Tech Serve Solutions supplies Tyrphostin A9 as a laboratory reagent. The specific grade and purity are available on the product's Certificate of Analysis. TSS does not represent this product as USP, BP, or EP grade.
What are the primary safety hazards associated with Tyrphostin A9?
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Tyrphostin A9 is classified as acutely toxic by ingestion, skin contact, and inhalation (H301-H311-H331), with the signal word 'Danger'. Appropriate personal protective equipment, including eyeshields, faceshields, gloves, and P2 respirator cartridges, is essential for safe handling. Full details are provided in the safety data sheet.
How is Tyrphostin A9 packed, shipped, and exported?
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Tyrphostin A9 is carefully packed according to international shipping regulations for hazardous materials. TSS offers global export services for this product.
How can I request a sample or quote for Tyrphostin A9?
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To request a sample or a quote for Tyrphostin A9, please contact our sales department via the website or by phone, providing your contact details and desired quantity.
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