Tyrphostin 25

CAS 118409-58-8C10H6N2O3Biochemicals & Reagents

Tyrphostin 25 (CAS: 118409-58-8, Formula: C10H6N2O3) is a potent inhibitor of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase activity. With a molecular weight of 202.17, this compound is crucial for research into cell signalling pathways and cancer biology. Tyrphostin 25 is employed in studies investigating transcriptional repression and cell migration, making it a valuable reagent for biochemical and cell biology research.

IUPAC: (3,4,5-Trihydroxybenzylidene)malononitrile

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Tyrphostin 25 (C10H6N2O3) — chemical structure, CAS 118409-58-8; Life Science, fine chemical supplied by Tech Serve Solutions

Biochemicals and ReagentsCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand SubstratesKinase/Phosphatase BiologyP to QProtein Kinase Inhibitors

01 /Applications

Research into Transcriptional Repression

Tyrphostin 25 has been utilised in studies examining the effect of adenoviral oncoprotein E1a on transcriptional repression in cell models, such as HeLa cells.

Investigation of Cell Migration Inhibition

This compound has been used in research to investigate mechanisms of cell migration inhibition, specifically in models like IEC-6 cells.

EGFR Kinase Inhibition Studies

As an inhibitor of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase, Tyrphostin 25 is a key tool for exploring cellular responses regulated by this important signalling pathway.

02 /Properties

Molecular weight	202.17
Empirical formula	C10H6N2O3
Assay	≥98%
Solubility	DMSO: >50 mg/mL, clear, yellow to orange
Storage temperature	2-8°C
Application	Tyrphostin 25 has been used for studying its effect on transcriptional repression induced by the adenoviral oncoprotein, E1a, in HeLa cells1. Tyrphostin 25 has also been used to study the migration inhibition in IEC-6 cells2.

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

118409-58-8

MDL number

MFCD00133900

PubChem substance

24278753

05 /Additional specifications

Gene Information	human ... EGFR(1956)
Potency	3 μM IC50

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Tyrphostin 25 used for?

Tyrphostin 25 is used in research for studying its effects on transcriptional repression, cell migration inhibition, and as an inhibitor of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase activity.

What is the CAS number and formula for Tyrphostin 25?

The CAS number for Tyrphostin 25 is 118409-58-8, and its empirical formula is C10H6N2O3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Tyrphostin 25 with an assay of ≥98%. This product is intended for laboratory research use only and is not represented as USP, BP, EP, or any other pharmacopoeia grade.

How should Tyrphostin 25 be handled safely?

Handling Tyrphostin 25 requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Observe all safety guidelines for chemical handling.

How is Tyrphostin 25 packed, shipped, and exported?

Tyrphostin 25 is typically stored at 2-8°C. As a global supplier, Tech Serve Solutions handles the packing, shipping, and export of this chemical, adhering to all relevant regulations for international transport.